Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2307841..2308580 Replicon chromosome
Accession NZ_CP115672
Organism Enterobacter hormaechei strain 2020CK-00203

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag PF324_RS11030 Protein ID WP_003857133.1
Coordinates 2307841..2308326 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag PF324_RS11035 Protein ID WP_003857131.1
Coordinates 2308314..2308580 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF324_RS11005 (PF324_11005) 2303385..2304143 - 759 WP_017693420.1 trans-aconitate 2-methyltransferase -
PF324_RS11010 (PF324_11010) 2304228..2304812 - 585 WP_039270753.1 NUDIX domain-containing protein -
PF324_RS11015 (PF324_11015) 2304899..2305657 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
PF324_RS11020 (PF324_11020) 2305762..2307054 + 1293 WP_032648327.1 glycosyl hydrolase family 28 protein -
PF324_RS11025 (PF324_11025) 2307054..2307668 + 615 WP_080338042.1 NUDIX hydrolase -
PF324_RS11030 (PF324_11030) 2307841..2308326 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
PF324_RS11035 (PF324_11035) 2308314..2308580 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
PF324_RS11040 (PF324_11040) 2308644..2309573 - 930 WP_039270752.1 LysR family transcriptional regulator -
PF324_RS11045 (PF324_11045) 2309703..2311085 + 1383 WP_039270751.1 MFS transporter -
PF324_RS11050 (PF324_11050) 2311107..2312102 - 996 WP_271039689.1 DUF2891 domain-containing protein -
PF324_RS11055 (PF324_11055) 2312112..2313098 - 987 WP_023296632.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2294477..2308580 14103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T267254 WP_003857133.1 NZ_CP115672:c2308326-2307841 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT267254 WP_003857131.1 NZ_CP115672:c2308580-2308314 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References