Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 302935..303531 Replicon chromosome
Accession NZ_CP115672
Organism Enterobacter hormaechei strain 2020CK-00203

Toxin (Protein)


Gene name PumA Uniprot ID A0A7G3EX93
Locus tag PF324_RS01445 Protein ID WP_015570164.1
Coordinates 303229..303531 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A927HL08
Locus tag PF324_RS01440 Protein ID WP_023295755.1
Coordinates 302935..303222 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF324_RS01435 (PF324_01435) 301307..302938 + 1632 WP_003860350.1 Na/Pi cotransporter family protein -
PF324_RS01440 (PF324_01440) 302935..303222 - 288 WP_023295755.1 putative addiction module antidote protein Antitoxin
PF324_RS01445 (PF324_01445) 303229..303531 - 303 WP_015570164.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PF324_RS01450 (PF324_01450) 303729..304601 + 873 WP_003860347.1 23S rRNA pseudouridine(2604) synthase RluF -
PF324_RS01455 (PF324_01455) 304602..304874 - 273 WP_017382612.1 DUF3811 domain-containing protein -
PF324_RS01460 (PF324_01460) 304925..305869 - 945 WP_032672119.1 ketopantoate/pantoate/pantothenate transporter PanS -
PF324_RS01465 (PF324_01465) 305963..307312 - 1350 WP_006810501.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11425.18 Da        Isoelectric Point: 10.3736

>T267252 WP_015570164.1 NZ_CP115672:c303531-303229 [Enterobacter hormaechei]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRIYFKDQGNSIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10101.59 Da        Isoelectric Point: 5.7807

>AT267252 WP_023295755.1 NZ_CP115672:c303222-302935 [Enterobacter hormaechei]
MHKLTPYDPANALLDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G3EX93

Antitoxin

Source ID Structure

References