Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 898927..899404 Replicon chromosome
Accession NC_017351
Organism Staphylococcus aureus subsp. aureus 11819-97

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag MS7_RS04555 Protein ID WP_000052076.1
Coordinates 898927..899115 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag MS7_RS04560 Protein ID WP_001059690.1
Coordinates 899144..899404 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS7_RS04525 894969..895439 + 471 WP_000824472.1 hypothetical protein -
MS7_RS04530 895780..896466 + 687 WP_001566557.1 thermonuclease family protein -
MS7_RS04535 896823..897023 + 201 WP_001059082.1 cold-shock protein -
MS7_RS04540 897518..897736 - 219 WP_000005884.1 hypothetical protein -
MS7_RS04545 897798..898082 - 285 WP_001004394.1 hypothetical protein -
MS7_RS04550 898170..898739 - 570 WP_001106652.1 hypothetical protein -
MS7_RS04555 898927..899115 - 189 WP_000052076.1 hypothetical protein Toxin
MS7_RS04560 899144..899404 - 261 WP_001059690.1 hypothetical protein Antitoxin
MS7_RS04565 899745..899948 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
MS7_RS04570 899945..900181 - 237 WP_000368687.1 hypothetical protein -
MS7_RS04575 900406..900987 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
MS7_RS04580 901060..901677 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
MS7_RS04585 901833..902327 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
MS7_RS04590 902726..903148 - 423 WP_000974465.1 organic hydroperoxide resistance protein -
MS7_RS04595 903296..904012 + 717 WP_000150020.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T26725 WP_000052076.1 NC_017351:c899115-898927 [Staphylococcus aureus subsp. aureus 11819-97]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T26725 NC_017351:c899115-898927 [Staphylococcus aureus subsp. aureus 11819-97]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT26725 WP_001059690.1 NC_017351:c899404-899144 [Staphylococcus aureus subsp. aureus 11819-97]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT26725 NC_017351:c899404-899144 [Staphylococcus aureus subsp. aureus 11819-97]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References