Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 2765667..2766220 Replicon chromosome
Accession NZ_CP115663
Organism Pseudomonas putida strain PD584_L3

Toxin (Protein)


Gene name parE Uniprot ID Q88JZ3
Locus tag PED35_RS12615 Protein ID WP_010953434.1
Coordinates 2765927..2766220 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q88JZ4
Locus tag PED35_RS12610 Protein ID WP_010953433.1
Coordinates 2765667..2765939 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PED35_RS12580 (PED35_12580) 2761239..2761598 - 360 Protein_2435 JAB domain-containing protein -
PED35_RS12585 (PED35_12585) 2761570..2762520 - 951 WP_031299400.1 hypothetical protein -
PED35_RS12590 (PED35_12590) 2762613..2763617 - 1005 WP_010953429.1 YqaJ viral recombinase family protein -
PED35_RS12595 (PED35_12595) 2763697..2764665 - 969 WP_031299399.1 DUF932 domain-containing protein -
PED35_RS12600 (PED35_12600) 2764763..2765092 - 330 WP_010953431.1 hypothetical protein -
PED35_RS12605 (PED35_12605) 2765297..2765542 + 246 WP_010953432.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
PED35_RS12610 (PED35_12610) 2765667..2765939 + 273 WP_010953433.1 CopG family ribbon-helix-helix protein Antitoxin
PED35_RS12615 (PED35_12615) 2765927..2766220 + 294 WP_010953434.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PED35_RS12620 (PED35_12620) 2766214..2767623 - 1410 WP_010953435.1 site-specific integrase -
PED35_RS12625 (PED35_12625) 2768146..2769072 - 927 WP_010953436.1 LysR family transcriptional regulator -
PED35_RS12630 (PED35_12630) 2769186..2769917 + 732 WP_010953437.1 SDR family NAD(P)-dependent oxidoreductase -
PED35_RS12635 (PED35_12635) 2769987..2770196 + 210 WP_010953438.1 4-oxalocrotonate tautomerase family protein -
PED35_RS12640 (PED35_12640) 2770193..2770405 + 213 WP_061405625.1 hypothetical protein -
PED35_RS12645 (PED35_12645) 2770548..2771066 + 519 WP_049587643.1 DUF1993 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11155.61 Da        Isoelectric Point: 5.9081

>T267231 WP_010953434.1 NZ_CP115663:2765927-2766220 [Pseudomonas putida]
VPRLIVTEGAAKGLERCRRFLSDKDPQVARRAAQAIERQFARLEESPEVGRPFPDLPELRELIIEFGDSGYVALYRYERA
DDTAYVLAFRHQKEAGY

Download         Length: 294 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10373.53 Da        Isoelectric Point: 5.5744

>AT267231 WP_010953433.1 NZ_CP115663:2765667-2765939 [Pseudomonas putida]
MATSIKIDDDLKGRIQHLACLRQRSSHWIMREAITQYVEREEARESFKQEALASWAAYQETGQHLTGQEARTWLGSWGTD
AEAELPKCHD

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W5CNE8

Antitoxin

Source ID Structure
AlphaFold DB Q88JZ4

References