Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 887271..887926 Replicon chromosome
Accession NZ_CP115654
Organism Neisseria gonorrhoeae strain FA1090 N-1-60

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag OK783_RS04610 Protein ID WP_003691083.1
Coordinates 887271..887690 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag OK783_RS04615 Protein ID WP_003688410.1
Coordinates 887690..887926 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK783_RS04590 (OK783_04590) 882505..884046 - 1542 WP_003688418.1 MDR family MFS transporter -
OK783_RS04595 (OK783_04595) 884194..884973 + 780 WP_003702609.1 (Fe-S)-binding protein -
OK783_RS04600 (OK783_04600) 884970..885671 + 702 WP_003688414.1 lactate utilization protein C -
OK783_RS04605 (OK783_04605) 885668..887122 + 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
OK783_RS04610 (OK783_04610) 887271..887690 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
OK783_RS04615 (OK783_04615) 887690..887926 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
OK783_RS04620 (OK783_04620) 888132..888953 - 822 WP_003706481.1 IS3 family transposase -
OK783_RS04625 (OK783_04625) 888958..889359 - 402 WP_020997337.1 helix-turn-helix domain-containing protein -
OK783_RS04630 (OK783_04630) 889598..889984 + 387 Protein_908 IS110 family transposase -
OK783_RS04635 (OK783_04635) 890367..891257 - 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
OK783_RS04640 (OK783_04640) 891268..892434 - 1167 WP_003701280.1 ADP-forming succinate--CoA ligase subunit beta -
OK783_RS04645 (OK783_04645) 892506..892793 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 889577..890050 473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T267208 WP_003691083.1 NZ_CP115654:c887690-887271 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT267208 WP_003688410.1 NZ_CP115654:c887926-887690 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References