Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3477561..3478214 Replicon chromosome
Accession NZ_CP115623
Organism Acinetobacter baumannii strain 2022CK-00340

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag PF449_RS16660 Protein ID WP_025467596.1
Coordinates 3477561..3477950 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag PF449_RS16665 Protein ID WP_001288210.1
Coordinates 3477957..3478214 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF449_RS16645 (PF449_16645) 3472679..3474874 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
PF449_RS16650 (PF449_16650) 3475062..3475628 - 567 WP_000651536.1 rhombosortase -
PF449_RS16655 (PF449_16655) 3475706..3476791 - 1086 WP_000049106.1 hypothetical protein -
PF449_RS16660 (PF449_16660) 3477561..3477950 - 390 WP_025467596.1 membrane protein Toxin
PF449_RS16665 (PF449_16665) 3477957..3478214 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
PF449_RS16670 (PF449_16670) 3478402..3479574 + 1173 WP_031961342.1 acyl-CoA dehydrogenase family protein -
PF449_RS16675 (PF449_16675) 3479623..3481113 - 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
PF449_RS16680 (PF449_16680) 3481295..3481672 - 378 WP_001216380.1 50S ribosomal protein L17 -
PF449_RS16685 (PF449_16685) 3481691..3482698 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15609.84 Da        Isoelectric Point: 10.3816

>T267192 WP_025467596.1 NZ_CP115623:c3477950-3477561 [Acinetobacter baumannii]
MINHLNFQLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLH

Download         Length: 390 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT267192 WP_001288210.1 NZ_CP115623:c3478214-3477957 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References