267191

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 13198..13786 Replicon plasmid unnamed1
Accession NZ_CP115622
Organism Acinetobacter baumannii strain 2022CK-00480

Toxin (Protein)


Gene name brnT Uniprot ID A0A0J8TIH5
Locus tag PF364_RS19075 Protein ID WP_000438827.1
Coordinates 13198..13485 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag PF364_RS19080 Protein ID WP_001983304.1
Coordinates 13472..13786 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PF364_RS19045 (PF364_19045) 8314..11052 + 2739 WP_261469658.1 AAA family ATPase -
PF364_RS19050 (PF364_19050) 11056..11268 + 213 WP_000687427.1 hypothetical protein -
PF364_RS19055 (PF364_19055) 11550..11726 + 177 WP_000246872.1 hypothetical protein -
PF364_RS19060 (PF364_19060) 11762..12256 + 495 WP_000999995.1 hypothetical protein -
PF364_RS19065 (PF364_19065) 12271..12555 - 285 WP_001071102.1 hypothetical protein -
PF364_RS19070 (PF364_19070) 12649..12951 + 303 WP_000702763.1 hypothetical protein -
PF364_RS19075 (PF364_19075) 13198..13485 + 288 WP_000438827.1 BrnT family toxin Toxin
PF364_RS19080 (PF364_19080) 13472..13786 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
PF364_RS19085 (PF364_19085) 13914..16325 + 2412 WP_000932942.1 TonB-dependent receptor ZnuD2 -
PF364_RS19090 (PF364_19090) 16630..17091 + 462 WP_000761346.1 DIP1984 family protein -
PF364_RS19095 (PF364_19095) 17417..17626 - 210 WP_000069474.1 hypothetical protein -
PF364_RS19100 (PF364_19100) 17619..17921 - 303 WP_001140621.1 XRE family transcriptional regulator -
PF364_RS19105 (PF364_19105) 17914..18270 - 357 WP_000269909.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..18774 18774


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11329.75 Da        Isoelectric Point: 5.6762

>T267191 WP_000438827.1 NZ_CP115622:13198-13485 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRYTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT267191 WP_001983304.1 NZ_CP115622:13472-13786 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TIH5

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References