267189

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1244795..1245712 Replicon chromosome
Accession NZ_CP115604
Organism Bacillus velezensis strain FJAT-54560

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A6A8LGT8
Locus tag PAN99_RS06545 Protein ID WP_003154806.1
Coordinates 1244966..1245712 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag PAN99_RS06540 Protein ID WP_003154807.1
Coordinates 1244795..1244965 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAN99_RS06505 (PAN99_06505) 1240027..1241649 + 1623 WP_003154821.1 pyocin knob domain-containing protein -
PAN99_RS06510 (PAN99_06510) 1241662..1242033 + 372 WP_014304856.1 XkdW family protein -
PAN99_RS06515 (PAN99_06515) 1242039..1242236 + 198 WP_044053582.1 XkdX family protein -
PAN99_RS06520 (PAN99_06520) 1242293..1243054 + 762 WP_044053129.1 hypothetical protein -
PAN99_RS06525 (PAN99_06525) 1243106..1243369 + 264 WP_003154815.1 hemolysin XhlA family protein -
PAN99_RS06530 (PAN99_06530) 1243383..1243646 + 264 WP_003154813.1 phage holin -
PAN99_RS06535 (PAN99_06535) 1243660..1244538 + 879 WP_024085195.1 N-acetylmuramoyl-L-alanine amidase -
PAN99_RS06540 (PAN99_06540) 1244795..1244965 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
PAN99_RS06545 (PAN99_06545) 1244966..1245712 - 747 WP_003154806.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
PAN99_RS06550 (PAN99_06550) 1245816..1246814 - 999 WP_003154805.1 inorganic phosphate transporter -
PAN99_RS06555 (PAN99_06555) 1246827..1247444 - 618 WP_003154804.1 DUF47 domain-containing protein -
PAN99_RS06560 (PAN99_06560) 1247730..1249046 - 1317 WP_044053130.1 amino acid permease -
PAN99_RS06565 (PAN99_06565) 1249370..1250320 + 951 WP_014304860.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29034.50 Da        Isoelectric Point: 4.6947

>T267189 WP_003154806.1 NZ_CP115604:c1245712-1244966 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVVGAMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYGEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQDRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT267189 WP_003154807.1 NZ_CP115604:c1244965-1244795 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A8LGT8

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References