Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4270759..4271335 Replicon chromosome
Accession NZ_CP115551
Organism Salmonella enterica subsp. enterica serovar Bispebjerg strain 20SAL-1342-3

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag PEE20_RS21475 Protein ID WP_001131963.1
Coordinates 4271048..4271335 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A6C6ZAR7
Locus tag PEE20_RS21470 Protein ID WP_000063143.1
Coordinates 4270759..4271061 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PEE20_RS21455 (4267269) 4267269..4269419 + 2151 WP_000379929.1 pyruvate/proton symporter BtsT -
PEE20_RS21460 (4269514) 4269514..4269717 + 204 WP_000460616.1 YbdD/YjiX family protein -
PEE20_RS21465 (4269728) 4269728..4270684 + 957 WP_000187838.1 GTPase -
PEE20_RS21470 (4270759) 4270759..4271061 - 303 WP_000063143.1 BrnA antitoxin family protein Antitoxin
PEE20_RS21475 (4271048) 4271048..4271335 - 288 WP_001131963.1 BrnT family toxin Toxin
PEE20_RS21480 (4271745) 4271745..4273586 + 1842 WP_020839636.1 nuclease-related domain-containing DEAD/DEAH box helicase -
PEE20_RS21485 (4274199) 4274199..4274774 + 576 WP_000593785.1 restriction endonuclease subunit S -
PEE20_RS21490 (4274767) 4274767..4276032 + 1266 WP_228412076.1 N-6 DNA methylase -
PEE20_RS21495 (4276064) 4276064..4276198 - 135 WP_001055726.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(40-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T267182 WP_001131963.1 NZ_CP115551:c4271335-4271048 [Salmonella enterica subsp. enterica serovar Bispebjerg]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11402.01 Da        Isoelectric Point: 10.1293

>AT267182 WP_000063143.1 NZ_CP115551:c4271061-4270759 [Salmonella enterica subsp. enterica serovar Bispebjerg]
MSMVKHKRGNASALSAQHEAELKALVKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6ZAR7

References