267181

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3675112..3675732 Replicon chromosome
Accession NZ_CP115551
Organism Salmonella enterica subsp. enterica serovar Bispebjerg strain 20SAL-1342-3

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PEE20_RS18700 Protein ID WP_001280991.1
Coordinates 3675514..3675732 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PEE20_RS18695 Protein ID WP_000344807.1
Coordinates 3675112..3675486 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PEE20_RS18685 (3670251) 3670251..3671444 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PEE20_RS18690 (3671467) 3671467..3674616 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PEE20_RS18695 (3675112) 3675112..3675486 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PEE20_RS18700 (3675514) 3675514..3675732 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PEE20_RS18705 (3675911) 3675911..3676462 + 552 WP_001278792.1 maltose O-acetyltransferase -
PEE20_RS18710 (3676579) 3676579..3677049 + 471 WP_000136181.1 YlaC family protein -
PEE20_RS18715 (3677105) 3677105..3677245 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PEE20_RS18720 (3677251) 3677251..3677511 - 261 WP_079787602.1 type B 50S ribosomal protein L31 -
PEE20_RS18725 (3677736) 3677736..3679286 + 1551 WP_270804766.1 EAL domain-containing protein -
PEE20_RS18735 (3679517) 3679517..3679906 + 390 WP_000961285.1 MGMT family protein -
PEE20_RS18740 (3679939) 3679939..3680508 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T267181 WP_001280991.1 NZ_CP115551:3675514-3675732 [Salmonella enterica subsp. enterica serovar Bispebjerg]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT267181 WP_000344807.1 NZ_CP115551:3675112-3675486 [Salmonella enterica subsp. enterica serovar Bispebjerg]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References