Detailed information of TA system TA267180

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-YafN
• Location: 2427719..2428241
• Replicon: chromosome
• Accession: NZ_CP115551
• Organism: Salmonella enterica subsp. enterica serovar Bispebjerg strain 20SAL-1342-3

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: B5F5Y5
• Locus tag: PEE20_RS12015
• Protein ID: WP_000221343.1
• Coordinates: 2427957..2428241 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: V1H457
• Locus tag: PEE20_RS12010
• Protein ID: WP_000885424.1
• Coordinates: 2427719..2427967 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PEE20_RS11990 (2423507)	2423507..2424514	-	1008	WP_000201080.1	LacI family DNA-binding transcriptional regulator	-
PEE20_RS11995 (2424844)	2424844..2425032	+	189	WP_001276020.1	DUF29 family protein	-
PEE20_RS12000 (2425370)	2425370..2426767	+	1398	WP_270806769.1	ISNCY family transposase	-
PEE20_RS12005 (2426871)	2426871..2427203	-	333	WP_270806770.1	DUF1493 family protein	-
PEE20_RS12010 (2427719)	2427719..2427967	+	249	WP_000885424.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
PEE20_RS12015 (2427957)	2427957..2428241	+	285	WP_000221343.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PEE20_RS12020 (2428289)	2428289..2428489	+	201	Protein_2353	Rid family hydrolase	-
PEE20_RS12025 (2428541)	2428541..2429620	-	1080	WP_270806771.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
PEE20_RS12030 (2429813)	2429813..2430301	-	489	WP_023261341.1	MarR family winged helix-turn-helix transcriptional regulator	-
PEE20_RS12035 (2430346)	2430346..2431854	+	1509	WP_000199415.1	FAD-dependent oxidoreductase	-
PEE20_RS12040 (2431844)	2431844..2433085	+	1242	WP_270806772.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2425370..2426767	1397

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11075.85 Da
• Isoelectric Point: 10.6500

>T267180 WP_000221343.1 NZ_CP115551:2427957-2428241 [Salmonella enterica subsp. enterica serovar Bispebjerg]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Nucleotide

• Length: 285 bp

>T267180 NZ_CP115551:2427957-2428241 [Salmonella enterica subsp. enterica serovar Bispebjerg]
ATGACTTATAAGCTGGCATTTAACGAATCTGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTACGGGAACGGCTCGAAAACCCTCGGGTTCCTGCTTCGCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGGCACAGAAGCTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9090.32 Da
• Isoelectric Point: 3.9820

>AT267180 WP_000885424.1 NZ_CP115551:2427719-2427967 [Salmonella enterica subsp. enterica serovar Bispebjerg]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Nucleotide

• Length: 249 bp

>AT267180 NZ_CP115551:2427719-2427967 [Salmonella enterica subsp. enterica serovar Bispebjerg]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGACCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Structures

Toxin

• AlphaFold DB: A0A5H5JSW4

Antitoxin

• AlphaFold DB: A0A5I0WPN5