Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1926633..1927409 Replicon chromosome
Accession NC_017349
Organism Staphylococcus aureus subsp. aureus LGA251

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag SARLGA251_RS09405 Protein ID WP_000031108.1
Coordinates 1926633..1926785 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag SARLGA251_RS09410 Protein ID WP_001251219.1
Coordinates 1926810..1927409 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SARLGA251_RS09385 1922637..1923458 + 822 WP_000669377.1 RluA family pseudouridine synthase -
SARLGA251_RS09390 1923908..1925293 - 1386 WP_000116236.1 class II fumarate hydratase -
SARLGA251_RS09395 1925489..1925884 - 396 WP_000901023.1 hypothetical protein -
SARLGA251_RS09405 1926633..1926785 - 153 WP_000031108.1 hypothetical protein Toxin
SARLGA251_RS09410 1926810..1927409 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
SARLGA251_RS09415 1927568..1928038 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
SARLGA251_RS09420 1928043..1929170 - 1128 WP_000379981.1 tRNA epoxyqueuosine(34) reductase QueG -
SARLGA251_RS09425 1929321..1930043 - 723 WP_041201594.1 amino acid ABC transporter ATP-binding protein -
SARLGA251_RS09430 1930036..1931493 - 1458 WP_000649902.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T26718 WP_000031108.1 NC_017349:c1926785-1926633 [Staphylococcus aureus subsp. aureus LGA251]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T26718 NC_017349:c1926785-1926633 [Staphylococcus aureus subsp. aureus LGA251]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT26718 WP_001251219.1 NC_017349:c1927409-1926810 [Staphylococcus aureus subsp. aureus LGA251]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT26718 NC_017349:c1927409-1926810 [Staphylococcus aureus subsp. aureus LGA251]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACTGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATATTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCTGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References