Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 1029448..1030262 | Replicon | chromosome |
| Accession | NZ_CP115551 | ||
| Organism | Salmonella enterica subsp. enterica serovar Bispebjerg strain 20SAL-1342-3 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | Q57KM2 |
| Locus tag | PEE20_RS05020 | Protein ID | WP_000971655.1 |
| Coordinates | 1029448..1029975 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | PEE20_RS05025 | Protein ID | WP_000855694.1 |
| Coordinates | 1029972..1030262 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PEE20_RS04990 (1025406) | 1025406..1026074 | + | 669 | WP_000445914.1 | hypothetical protein | - |
| PEE20_RS04995 (1026101) | 1026101..1026304 | + | 204 | Protein_979 | hypothetical protein | - |
| PEE20_RS05000 (1026358) | 1026358..1027613 | + | 1256 | WP_086016038.1 | IS3-like element ISSen1 family transposase | - |
| PEE20_RS05005 (1027794) | 1027794..1027910 | + | 117 | Protein_981 | hypothetical protein | - |
| PEE20_RS05010 (1028155) | 1028155..1028811 | - | 657 | WP_000420452.1 | protein-serine/threonine phosphatase | - |
| PEE20_RS05015 (1029170) | 1029170..1029375 | + | 206 | Protein_983 | IS5/IS1182 family transposase | - |
| PEE20_RS05020 (1029448) | 1029448..1029975 | - | 528 | WP_000971655.1 | GNAT family N-acetyltransferase | Toxin |
| PEE20_RS05025 (1029972) | 1029972..1030262 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| PEE20_RS05030 (1030532) | 1030532..1030732 | - | 201 | Protein_986 | transposase | - |
| PEE20_RS05035 (1031136) | 1031136..1031579 | - | 444 | WP_151117339.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| PEE20_RS05040 (1032035) | 1032035..1032685 | + | 651 | WP_001674874.1 | type III secretion system transcriptional activator InvF | - |
| PEE20_RS05045 (1032682) | 1032682..1034370 | + | 1689 | WP_000848102.1 | type III secretion system outer membrane ring protein InvG | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19069.91 Da Isoelectric Point: 9.6420
>T267175 WP_000971655.1 NZ_CP115551:c1029975-1029448 [Salmonella enterica subsp. enterica serovar Bispebjerg]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT267175 WP_000855694.1 NZ_CP115551:c1030262-1029972 [Salmonella enterica subsp. enterica serovar Bispebjerg]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 6G96 | |
| PDB | 7AK9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V8SJE7 |