Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 205515..206275 Replicon chromosome
Accession NZ_CP115551
Organism Salmonella enterica subsp. enterica serovar Bispebjerg strain 20SAL-1342-3

Toxin (Protein)


Gene name tacT Uniprot ID A0A4D6P0H3
Locus tag PEE20_RS00965 Protein ID WP_000533911.1
Coordinates 205790..206275 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag PEE20_RS00960 Protein ID WP_000965886.1
Coordinates 205515..205802 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PEE20_RS00945 (201013) 201013..203082 + 2070 WP_270805560.1 glycine--tRNA ligase subunit beta -
PEE20_RS00950 (203472) 203472..203870 + 399 Protein_188 IS3 family transposase -
PEE20_RS00955 (204264) 204264..205169 + 906 WP_151115268.1 hypothetical protein -
PEE20_RS00960 (205515) 205515..205802 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
PEE20_RS00965 (205790) 205790..206275 + 486 WP_000533911.1 GNAT family N-acetyltransferase Toxin
PEE20_RS00970 (206649) 206649..207188 - 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
PEE20_RS00975 (207361) 207361..207573 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
PEE20_RS00980 (207862) 207862..208152 - 291 WP_000455790.1 HTH-type transcriptional regulator -
PEE20_RS00985 (208591) 208591..209301 + 711 WP_080214401.1 DUF3053 domain-containing protein -
PEE20_RS00990 (209351) 209351..210325 - 975 WP_000804688.1 glyoxylate/hydroxypyruvate reductase GhrB -
PEE20_RS00995 (210544) 210544..211206 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17751.50 Da        Isoelectric Point: 10.0066

>T267171 WP_000533911.1 NZ_CP115551:205790-206275 [Salmonella enterica subsp. enterica serovar Bispebjerg]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVYLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT267171 WP_000965886.1 NZ_CP115551:205515-205802 [Salmonella enterica subsp. enterica serovar Bispebjerg]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4D6P0H3

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References