Detailed information of TA system TA026717

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 839287..839764
• Replicon: chromosome
• Accession: NC_017349
• Organism: Staphylococcus aureus subsp. aureus LGA251

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: SARLGA251_RS03965
• Protein ID: WP_000052076.1
• Coordinates: 839287..839475 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: SARLGA251_RS03970
• Protein ID: WP_001059687.1
• Coordinates: 839504..839764 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SARLGA251_RS03935	835276..835797	+	522	WP_000824476.1	hypothetical protein	-
SARLGA251_RS03940	836138..836824	+	687	WP_000141556.1	thermonuclease family protein	-
SARLGA251_RS03945	837181..837381	+	201	WP_001059082.1	cold-shock protein	-
SARLGA251_RS03950	837878..838096	-	219	WP_000005883.1	hypothetical protein	-
SARLGA251_RS03955	838158..838442	-	285	WP_001004401.1	hypothetical protein	-
SARLGA251_RS03960	838530..839099	-	570	WP_001106648.1	hypothetical protein	-
SARLGA251_RS03965	839287..839475	-	189	WP_000052076.1	hypothetical protein	Toxin
SARLGA251_RS03970	839504..839764	-	261	WP_001059687.1	hypothetical protein	Antitoxin
SARLGA251_RS03975	840105..840308	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
SARLGA251_RS03980	840305..840541	-	237	WP_000368687.1	hypothetical protein	-
SARLGA251_RS03985	840766..841347	+	582	WP_001140696.1	phosphoglycerate mutase family protein	-
SARLGA251_RS03990	841420..842037	-	618	WP_000255565.1	LysE/ArgO family amino acid transporter	-
SARLGA251_RS03995	842193..842687	-	495	WP_000569881.1	GNAT family N-acetyltransferase	-
SARLGA251_RS04000	843086..843508	-	423	WP_000974462.1	organic hydroperoxide resistance protein	-
SARLGA251_RS04005	843656..844372	+	717	WP_000150032.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T26717 WP_000052076.1 NC_017349:c839475-839287 [Staphylococcus aureus subsp. aureus LGA251]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T26717 NC_017349:c839475-839287 [Staphylococcus aureus subsp. aureus LGA251]
ATGTCTTTACATTTTGCAATTCTTTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAATCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9998.13 Da
• Isoelectric Point: 3.8841

>AT26717 WP_001059687.1 NC_017349:c839764-839504 [Staphylococcus aureus subsp. aureus LGA251]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICDVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT26717 NC_017349:c839764-839504 [Staphylococcus aureus subsp. aureus LGA251]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGATGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18