Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2763663..2765311 Replicon chromosome
Accession NZ_CP115464
Organism Brevundimonas sp. NIBR10

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag O5K39_RS13605 Protein ID WP_271144155.1
Coordinates 2763663..2764961 (-) Length 433 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag O5K39_RS13610 Protein ID WP_271144156.1
Coordinates 2764958..2765311 (-) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O5K39_RS13595 (KOAAANKH_02706) 2760309..2761745 + 1437 WP_271144153.1 M20/M25/M40 family metallo-hydrolase -
O5K39_RS13600 (KOAAANKH_02707) 2761974..2763257 + 1284 WP_271144154.1 site-specific integrase -
O5K39_RS13605 (KOAAANKH_02708) 2763663..2764961 - 1299 WP_271144155.1 type II toxin-antitoxin system HipA family toxin Toxin
O5K39_RS13610 (KOAAANKH_02709) 2764958..2765311 - 354 WP_271144156.1 helix-turn-helix transcriptional regulator Antitoxin
O5K39_RS13615 (KOAAANKH_02710) 2766100..2766999 + 900 WP_271144157.1 endonuclease/exonuclease/phosphatase family protein -
O5K39_RS13620 (KOAAANKH_02711) 2767013..2767612 - 600 WP_271144158.1 hypothetical protein -
O5K39_RS13625 (KOAAANKH_02712) 2767672..2768577 + 906 WP_271144159.1 hypothetical protein -
O5K39_RS13630 (KOAAANKH_02713) 2768490..2769500 + 1011 WP_271144160.1 hypothetical protein -
O5K39_RS13635 (KOAAANKH_02714) 2769540..2770124 - 585 WP_271144161.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-115)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-65)


Sequences

Toxin        


Download         Length: 433 a.a.        Molecular weight: 47948.08 Da        Isoelectric Point: 5.0859

>T267164 WP_271144155.1 NZ_CP115464:c2764961-2763663 [Brevundimonas sp. NIBR10]
MTIAAVNLWGRRIGAVSLAEGADVATFAYEPAFLRSQIEVAPLFMPLSDRIYSFSGLNPESFYGLPGMLADALPDRYGHT
LINAWLATQGRTPDSADAVERLCYMASRGMGALEFTPAAGPRTRKSERVHIETLVELASEVLTNRNTLQVSFGDPDKADA
LREILQVGASAGGARAKAIIAWNPDTNEVRSGQVDAGDGFSYWLLKFDGVSDNRDRGLADPQGFGAVEFAYSEMAKAAGI
NMTDCRLLPEGGRRHFMTRRFDRTETGGKLHMQSLAALAHYDYCSPDSYTYEQAFQVMRQLNLPMDQMEELFRRMTFNVV
ARNQDDHVKNIAFLMDRNGVWSLSPAYDVTWALDLTNQWLRQHQMSVNGRRKDISRADLEACAATASINATRARAIIDEV
VATVADWPRFAEAAEVDDFMRKSIDPSLKADF

Download         Length: 1299 bp

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 13294.02 Da        Isoelectric Point: 7.0195

>AT267164 WP_271144156.1 NZ_CP115464:c2765311-2764958 [Brevundimonas sp. NIBR10]
MKVTNLTTDQAVLTEVGRRMADYRLQRHMTQSQFAEAAGVSKRTVERLEAGDSVQLINLVRALRVLEKLDGLDRFLPDAP
ANPIDLLERQGKVRQRARPDARPDDDATQPWRWGDEA

Download         Length: 354 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References