Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 215087..216600 Replicon plasmid pKN1
Accession NZ_CP115457
Organism Sphingobium yanoikuyae strain CC4533

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag PAE53_RS23435 Protein ID WP_270094097.1
Coordinates 215353..216600 (+) Length 416 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag PAE53_RS23430 Protein ID WP_214866471.1
Coordinates 215087..215356 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAE53_RS23410 (PAE53_23410) 210266..210529 - 264 WP_270094093.1 hypothetical protein -
PAE53_RS23415 (PAE53_23415) 210646..211224 + 579 WP_270094094.1 PAS domain-containing protein -
PAE53_RS23420 (PAE53_23420) 211221..213086 - 1866 WP_270094095.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
PAE53_RS23425 (PAE53_23425) 213225..214697 + 1473 WP_270094096.1 phytoene desaturase -
PAE53_RS23430 (PAE53_23430) 215087..215356 + 270 WP_214866471.1 helix-turn-helix domain-containing protein Antitoxin
PAE53_RS23435 (PAE53_23435) 215353..216600 + 1248 WP_270094097.1 type II toxin-antitoxin system HipA family toxin Toxin
PAE53_RS23440 (PAE53_23440) 216958..217206 - 249 Protein_193 IS110 family transposase -
PAE53_RS23445 (PAE53_23445) 217212..218249 + 1038 Protein_194 IS110 family transposase -
PAE53_RS23450 (PAE53_23450) 218605..220212 - 1608 WP_270094098.1 tyrosine-type recombinase/integrase -
PAE53_RS23455 (PAE53_23455) 220415..221383 + 969 WP_270094100.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..647509 647509
- flank IS/Tn - - 217212..217595 383


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(141-368)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-74)


Sequences

Toxin        


Download         Length: 416 a.a.        Molecular weight: 45648.64 Da        Isoelectric Point: 6.8773

>T267154 WP_270094097.1 NZ_CP115457:215353-216600 [Sphingobium yanoikuyae]
MIALPVFFGSRHVGDVVHENGPRFIYDEVWLGSRDAFPISTSMPLQTKHVPAETLLPWAANLLPEAEQLTMVGRQLGIAP
GDILGMLSAIGRDTAGALSFGAPGLTSEKFWKPIREETDLERIIEELPQKPFLAGDDGVSMSLAGVQTKLALAQDVNGTL
HVPLEGAPSTHILKPDSDRLVGSVQNEAFCLTLARLCGLTVPAITTGKAGKRQYFLIERYDRVQRDDEWVRLHQEDFCQA
LGRYPSEKYERNSSGRGPTIVDMVGILRKHGLAPDALSMIDYVAFNILVCNTDAHAKNYSLMVQPGMARLAPLYDVMCAD
PYDGITRNLAQTIAGESRGDHIKQRQWVRMLEAGKFQPRLMLRRIHRLATSVLGNLEKALAQVDAMPAGGHAIMPAVMRA
VERRSRAVLAGLEEL

Download         Length: 1248 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9653.94 Da        Isoelectric Point: 6.4787

>AT267154 WP_214866471.1 NZ_CP115457:215087-215356 [Sphingobium yanoikuyae]
MHENLLEDAASYSRRFGAMIRREREAHGLRLEDLSAATGVGIRFLHDLETGKPTCQIGRSLVVAAAIGLDAIKLLELASE
PHDGQGSSR

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References