Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3831066..3831751 Replicon chromosome
Accession NZ_CP115447
Organism Mycobacterium tuberculosis strain BLR 9248 2019

Toxin (Protein)


Gene name vapC Uniprot ID G0TIR9
Locus tag PAK35_RS17980 Protein ID WP_003417998.1
Coordinates 3831341..3831751 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PAK35_RS17975 Protein ID WP_180895138.1
Coordinates 3831066..3831344 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAK35_RS17955 (PAK35_17955) 3827055..3828656 - 1602 WP_003417969.1 FAD/NAD(P)-binding protein -
PAK35_RS17960 (PAK35_17960) 3828673..3829377 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
PAK35_RS17965 (PAK35_17965) 3829495..3830061 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
PAK35_RS17970 (PAK35_17970) 3830123..3831010 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
PAK35_RS17975 (PAK35_17975) 3831066..3831344 + 279 WP_180895138.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PAK35_RS17980 (PAK35_17980) 3831341..3831751 + 411 WP_003417998.1 type II toxin-antitoxin system VapC family toxin Toxin
PAK35_RS17985 (PAK35_17985) 3831784..3833520 - 1737 WP_003418002.1 cholesterol oxidase -
PAK35_RS17990 (PAK35_17990) 3833576..3834703 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
PAK35_RS17995 (PAK35_17995) 3834723..3836312 - 1590 WP_003901630.1 IMP dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-58)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14695.84 Da        Isoelectric Point: 5.1784

>T267145 WP_003417998.1 NZ_CP115447:3831341-3831751 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10227.70 Da        Isoelectric Point: 8.0222

>AT267145 WP_180895138.1 NZ_CP115447:3831066-3831344 [Mycobacterium tuberculosis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGCKRT
LSDVLNEMRDEQ

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIR9

Antitoxin

Source ID Structure

References