Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3704313..3704938 Replicon chromosome
Accession NZ_CP115447
Organism Mycobacterium tuberculosis strain BLR 9248 2019

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag PAK35_RS17500 Protein ID WP_003403218.1
Coordinates 3704313..3704714 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag PAK35_RS17505 Protein ID WP_003403213.1
Coordinates 3704711..3704938 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAK35_RS17475 (PAK35_17475) 3699403..3700350 - 948 WP_003403232.1 DUF732 domain-containing protein -
PAK35_RS17480 (PAK35_17480) 3700454..3701518 - 1065 WP_003898532.1 zinc ribbon domain-containing protein -
PAK35_RS17485 (PAK35_17485) 3701913..3703004 - 1092 WP_003900977.1 galactokinase -
PAK35_RS17490 (PAK35_17490) 3703001..3704082 - 1082 Protein_3454 galactose-1-phosphate uridylyltransferase -
PAK35_RS17495 (PAK35_17495) 3704101..3704184 - 84 Protein_3455 galactose-1-phosphate uridylyltransferase -
PAK35_RS17500 (PAK35_17500) 3704313..3704714 - 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
PAK35_RS17505 (PAK35_17505) 3704711..3704938 - 228 WP_003403213.1 antitoxin VapB29 Antitoxin
PAK35_RS17510 (PAK35_17510) 3705133..3705375 - 243 WP_003403210.1 hypothetical protein -
PAK35_RS17515 (PAK35_17515) 3705372..3706121 - 750 WP_003898528.1 hypothetical protein -
PAK35_RS17520 (PAK35_17520) 3706205..3708772 + 2568 WP_003901879.1 SEC-C metal-binding domain-containing protein -
PAK35_RS17525 (PAK35_17525) 3708791..3709396 - 606 WP_003898526.1 hypothetical protein -
PAK35_RS17530 (PAK35_17530) 3709538..3709759 + 222 WP_003898525.1 DUF4926 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T267142 WP_003403218.1 NZ_CP115447:c3704714-3704313 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT267142 WP_003403213.1 NZ_CP115447:c3704938-3704711 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References