Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3698661..3699310 Replicon chromosome
Accession NZ_CP115447
Organism Mycobacterium tuberculosis strain BLR 9248 2019

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag PAK35_RS17465 Protein ID WP_003403236.1
Coordinates 3698661..3699056 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag PAK35_RS17470 Protein ID WP_003403235.1
Coordinates 3699056..3699310 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAK35_RS17440 (PAK35_17440) 3693988..3695715 + 1728 WP_003901883.1 exodeoxyribonuclease V subunit alpha -
PAK35_RS17445 (PAK35_17445) 3695808..3696959 + 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
PAK35_RS17450 (PAK35_17450) 3697031..3697438 - 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
PAK35_RS17455 (PAK35_17455) 3697435..3697695 - 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
PAK35_RS17460 (PAK35_17460) 3697827..3698567 + 741 WP_003403239.1 TVP38/TMEM64 family protein -
PAK35_RS17465 (PAK35_17465) 3698661..3699056 - 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
PAK35_RS17470 (PAK35_17470) 3699056..3699310 - 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
PAK35_RS17475 (PAK35_17475) 3699403..3700350 - 948 WP_003403232.1 DUF732 domain-containing protein -
PAK35_RS17480 (PAK35_17480) 3700454..3701518 - 1065 WP_003898532.1 zinc ribbon domain-containing protein -
PAK35_RS17485 (PAK35_17485) 3701913..3703004 - 1092 WP_003900977.1 galactokinase -
PAK35_RS17490 (PAK35_17490) 3703001..3704082 - 1082 Protein_3454 galactose-1-phosphate uridylyltransferase -
PAK35_RS17495 (PAK35_17495) 3704101..3704184 - 84 Protein_3455 galactose-1-phosphate uridylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T267141 WP_003403236.1 NZ_CP115447:c3699056-3698661 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT267141 WP_003403235.1 NZ_CP115447:c3699310-3699056 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References