Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 3697031..3697695 Replicon chromosome
Accession NZ_CP115447
Organism Mycobacterium tuberculosis strain BLR 9248 2019

Toxin (Protein)


Gene name vapC Uniprot ID P96917
Locus tag PAK35_RS17450 Protein ID WP_003403246.1
Coordinates 3697031..3697438 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WF18
Locus tag PAK35_RS17455 Protein ID WP_003403244.1
Coordinates 3697435..3697695 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAK35_RS17440 (PAK35_17440) 3693988..3695715 + 1728 WP_003901883.1 exodeoxyribonuclease V subunit alpha -
PAK35_RS17445 (PAK35_17445) 3695808..3696959 + 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
PAK35_RS17450 (PAK35_17450) 3697031..3697438 - 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin Toxin
PAK35_RS17455 (PAK35_17455) 3697435..3697695 - 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PAK35_RS17460 (PAK35_17460) 3697827..3698567 + 741 WP_003403239.1 TVP38/TMEM64 family protein -
PAK35_RS17465 (PAK35_17465) 3698661..3699056 - 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 -
PAK35_RS17470 (PAK35_17470) 3699056..3699310 - 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 -
PAK35_RS17475 (PAK35_17475) 3699403..3700350 - 948 WP_003403232.1 DUF732 domain-containing protein -
PAK35_RS17480 (PAK35_17480) 3700454..3701518 - 1065 WP_003898532.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-57)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14376.37 Da        Isoelectric Point: 4.3568

>T267140 WP_003403246.1 NZ_CP115447:c3697438-3697031 [Mycobacterium tuberculosis]
VSTTPAAGVLDTSVFIATESGRQLDEALIPDRVATTVVTLAELRVGVLAAATTDIRAQRLATLESVADMETLPVDDDAAR
MWARLRIHLAESGRRVRINDLWIAAVAASRALPVITQDDDFAALDGAASVEIIRV

Download         Length: 408 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9492.84 Da        Isoelectric Point: 11.9108

>AT267140 WP_003403244.1 NZ_CP115447:c3697695-3697435 [Mycobacterium tuberculosis]
MSEVASRELRNDTAGVLRRVRAGEDVTITVSGRPVAVLTPVRPRRRRWLSKTEFLSRLRGAQADPGLRNDLAVLAGDTTE
DLGPIR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3DBO

Antitoxin

Source ID Structure
PDB 3DBO
AlphaFold DB A0A7U4BSE4

References