Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 3659415..3660207 Replicon chromosome
Accession NZ_CP115447
Organism Mycobacterium tuberculosis strain BLR 9248 2019

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag PAK35_RS17255 Protein ID WP_003403386.1
Coordinates 3659415..3659852 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag PAK35_RS17260 Protein ID WP_003403381.1
Coordinates 3659962..3660207 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAK35_RS17230 (PAK35_17230) 3655878..3656051 - 174 WP_003898549.1 hypothetical protein -
PAK35_RS17235 (PAK35_17235) 3656048..3656386 - 339 WP_003403405.1 PIN domain-containing protein -
PAK35_RS17240 (PAK35_17240) 3656298..3656624 - 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
PAK35_RS17245 (PAK35_17245) 3656687..3659050 - 2364 WP_003901895.1 arylsulfatase AtsD -
PAK35_RS17250 (PAK35_17250) 3659164..3659418 + 255 WP_003911263.1 antitoxin VapB7 -
PAK35_RS17255 (PAK35_17255) 3659415..3659852 + 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
PAK35_RS17260 (PAK35_17260) 3659962..3660207 + 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
PAK35_RS17265 (PAK35_17265) 3660194..3660502 + 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
PAK35_RS17270 (PAK35_17270) 3660778..3661494 + 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
PAK35_RS17275 (PAK35_17275) 3661570..3661725 + 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
PAK35_RS17280 (PAK35_17280) 3661820..3662203 + 384 WP_003403365.1 ribonuclease VapC6 -
PAK35_RS17285 (PAK35_17285) 3662591..3663601 - 1011 WP_003911248.1 ABC transporter ATP-binding protein -
PAK35_RS17290 (PAK35_17290) 3663682..3665187 - 1506 WP_003403360.1 carotenoid cleavage oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T267137 WP_003403386.1 NZ_CP115447:3659415-3659852 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT267137 WP_003403381.1 NZ_CP115447:3659962-3660207 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References