Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3573550..3574259 Replicon chromosome
Accession NZ_CP115447
Organism Mycobacterium tuberculosis strain BLR 9248 2019

Toxin (Protein)


Gene name vapC Uniprot ID P9WF74
Locus tag PAK35_RS16780 Protein ID WP_003403837.1
Coordinates 3573550..3573978 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PAK35_RS16785 Protein ID WP_050177415.1
Coordinates 3574002..3574259 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAK35_RS16755 (PAK35_16755) 3569253..3570785 + 1533 WP_003403847.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
PAK35_RS16760 (PAK35_16760) 3570792..3571964 + 1173 WP_003403845.1 acyl-CoA dehydrogenase family protein -
PAK35_RS16765 (PAK35_16765) 3571975..3572859 + 885 WP_003403844.1 3-hydroxyisobutyrate dehydrogenase -
PAK35_RS16770 (PAK35_16770) 3572928..3573173 - 246 WP_003403841.1 hypothetical protein -
PAK35_RS16775 (PAK35_16775) 3573332..3573469 + 138 WP_003403839.1 hypothetical protein -
PAK35_RS16780 (PAK35_16780) 3573550..3573978 - 429 WP_003403837.1 type II toxin-antitoxin system VapC family toxin Toxin
PAK35_RS16785 (PAK35_16785) 3574002..3574259 - 258 WP_050177415.1 ribbon-helix-helix protein, CopG family Antitoxin
PAK35_RS16790 (PAK35_16790) 3574350..3576623 - 2274 WP_016330384.1 PE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-39)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15831.27 Da        Isoelectric Point: 7.5536

>T267135 WP_003403837.1 NZ_CP115447:c3573978-3573550 [Mycobacterium tuberculosis]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHL
PTNPGPRHLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9101.28 Da        Isoelectric Point: 11.1777

>AT267135 WP_050177415.1 NZ_CP115447:c3574259-3574002 [Mycobacterium tuberculosis]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRRELAAARTGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDR3

Antitoxin

Source ID Structure

References