Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 3400187..3400806 Replicon chromosome
Accession NZ_CP115447
Organism Mycobacterium tuberculosis strain BLR 9248 2019

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag PAK35_RS15940 Protein ID WP_003404726.1
Coordinates 3400187..3400621 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag PAK35_RS15945 Protein ID WP_003898641.1
Coordinates 3400627..3400806 (-) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAK35_RS15915 (PAK35_15915) 3395522..3396760 + 1239 WP_003404744.1 acetyl-CoA acetyltransferase -
PAK35_RS15920 (PAK35_15920) 3396762..3398270 + 1509 WP_003404742.1 carotenoid oxygenase family protein -
PAK35_RS15925 (PAK35_15925) 3398437..3398667 + 231 WP_003898642.1 hypothetical protein -
PAK35_RS15930 (PAK35_15930) 3398802..3399251 - 450 WP_003404738.1 hypothetical protein -
PAK35_RS15935 (PAK35_15935) 3399316..3400089 - 774 WP_003404735.1 VOC family protein -
PAK35_RS15940 (PAK35_15940) 3400187..3400621 - 435 WP_003404726.1 SRPBCC family protein Toxin
PAK35_RS15945 (PAK35_15945) 3400627..3400806 - 180 WP_003898641.1 antitoxin Antitoxin
PAK35_RS15950 (PAK35_15950) 3400932..3401090 - 159 WP_003404720.1 hypothetical protein -
PAK35_RS15955 (PAK35_15955) 3401363..3403756 - 2394 WP_003898639.1 cation-translocating P-type ATPase -
PAK35_RS15960 (PAK35_15960) 3403753..3405333 - 1581 WP_003910977.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T267134 WP_003404726.1 NZ_CP115447:c3400621-3400187 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT267134 WP_003898641.1 NZ_CP115447:c3400806-3400627 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References