Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2952970..2953657 Replicon chromosome
Accession NZ_CP115447
Organism Mycobacterium tuberculosis strain BLR 9248 2019

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag PAK35_RS13925 Protein ID WP_003414624.1
Coordinates 2953214..2953657 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag PAK35_RS13920 Protein ID WP_003414620.1
Coordinates 2952970..2953227 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAK35_RS13900 (PAK35_13900) 2948290..2949144 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
PAK35_RS13905 (PAK35_13905) 2949200..2950363 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
PAK35_RS13910 (PAK35_13910) 2950380..2951594 - 1215 WP_003414610.1 zinc metalloprotease Rip -
PAK35_RS13915 (PAK35_13915) 2951602..2952843 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
PAK35_RS13920 (PAK35_13920) 2952970..2953227 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
PAK35_RS13925 (PAK35_13925) 2953214..2953657 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
PAK35_RS13930 (PAK35_13930) 2953737..2954399 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
PAK35_RS13935 (PAK35_13935) 2954495..2954686 + 192 WP_003414632.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
PAK35_RS13940 (PAK35_13940) 2955018..2956766 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
PAK35_RS13945 (PAK35_13945) 2956862..2957443 + 582 WP_003414644.1 fasciclin domain-containing protein -
PAK35_RS13950 (PAK35_13950) 2957543..2957809 + 267 WP_015456449.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T267130 WP_003414624.1 NZ_CP115447:2953214-2953657 [Mycobacterium tuberculosis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT267130 WP_003414620.1 NZ_CP115447:2952970-2953227 [Mycobacterium tuberculosis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References