267129

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 2947369..2947917 Replicon chromosome
Accession NZ_CP115447
Organism Mycobacterium tuberculosis strain BLR 9248 2019

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag PAK35_RS13895 Protein ID WP_003414602.1
Coordinates 2947654..2947917 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag PAK35_RS13890 Protein ID WP_003414599.1
Coordinates 2947369..2947650 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAK35_RS13865 (PAK35_13865) 2942993..2943850 - 858 WP_003899513.1 type I methionyl aminopeptidase -
PAK35_RS13870 (PAK35_13870) 2943892..2944476 - 585 WP_003414585.1 DUF1707 domain-containing protein -
PAK35_RS13875 (PAK35_13875) 2944579..2944827 + 249 WP_003913411.1 antitoxin VapB23 -
PAK35_RS13880 (PAK35_13880) 2944824..2945204 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
PAK35_RS13885 (PAK35_13885) 2945286..2947097 - 1812 WP_003414596.1 penicillin-binding protein -
PAK35_RS13890 (PAK35_13890) 2947369..2947650 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
PAK35_RS13895 (PAK35_13895) 2947654..2947917 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PAK35_RS13900 (PAK35_13900) 2948290..2949144 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
PAK35_RS13905 (PAK35_13905) 2949200..2950363 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
PAK35_RS13910 (PAK35_13910) 2950380..2951594 - 1215 WP_003414610.1 zinc metalloprotease Rip -
PAK35_RS13915 (PAK35_13915) 2951602..2952843 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T267129 WP_003414602.1 NZ_CP115447:2947654-2947917 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT267129 WP_003414599.1 NZ_CP115447:2947369-2947650 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWP8

References