267126

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2886254..2886824 Replicon chromosome
Accession NZ_CP115447
Organism Mycobacterium tuberculosis strain BLR 9248 2019

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag PAK35_RS13570 Protein ID WP_003414166.1
Coordinates 2886254..2886610 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag PAK35_RS13575 Protein ID WP_003901465.1
Coordinates 2886594..2886824 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAK35_RS13550 (PAK35_13550) 2881706..2883394 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
PAK35_RS13555 (PAK35_13555) 2883398..2883724 - 327 WP_003414157.1 hypothetical protein -
PAK35_RS13560 (PAK35_13560) 2883897..2884484 + 588 WP_003914429.1 DUF3558 family protein -
PAK35_RS13565 (PAK35_13565) 2884503..2886152 + 1650 Protein_2683 CocE/NonD family hydrolase -
PAK35_RS13570 (PAK35_13570) 2886254..2886610 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
PAK35_RS13575 (PAK35_13575) 2886594..2886824 - 231 WP_003901465.1 type II toxin-antitoxin system antitoxin MazE9 Antitoxin
PAK35_RS13580 (PAK35_13580) 2886867..2887910 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
PAK35_RS13585 (PAK35_13585) 2887909..2888376 + 468 WP_003414177.1 DUF1778 domain-containing protein -
PAK35_RS13590 (PAK35_13590) 2888552..2888806 - 255 WP_003917684.1 hypothetical protein -
PAK35_RS13595 (PAK35_13595) 2888954..2889358 + 405 WP_003414181.1 hypothetical protein -
PAK35_RS13600 (PAK35_13600) 2889355..2889546 + 192 WP_003414184.1 hypothetical protein -
PAK35_RS13605 (PAK35_13605) 2889763..2890023 + 261 Protein_2691 transposase -
PAK35_RS13610 (PAK35_13610) 2891133..2891390 + 258 WP_003899489.1 hypothetical protein -
PAK35_RS13615 (PAK35_13615) 2891495..2891806 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T267126 WP_003414166.1 NZ_CP115447:c2886610-2886254 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT267126 WP_003901465.1 NZ_CP115447:c2886824-2886594 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FBW3

References