Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2583927..2584579 Replicon chromosome
Accession NZ_CP115447
Organism Mycobacterium tuberculosis strain BLR 9248 2019

Toxin (Protein)


Gene name vapC Uniprot ID A0A5R1ZCY8
Locus tag PAK35_RS11945 Protein ID WP_003905869.1
Coordinates 2584154..2584579 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag PAK35_RS11940 Protein ID WP_003412749.1
Coordinates 2583927..2584148 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAK35_RS11925 (PAK35_11925) 2582167..2582373 - 207 WP_003899347.1 hypothetical protein -
PAK35_RS11930 (PAK35_11930) 2582509..2583132 + 624 WP_003900858.1 TIGR00725 family protein -
PAK35_RS11935 (PAK35_11935) 2583122..2583874 + 753 WP_003901416.1 hypothetical protein -
PAK35_RS11940 (PAK35_11940) 2583927..2584148 + 222 WP_003412749.1 antitoxin Antitoxin
PAK35_RS11945 (PAK35_11945) 2584154..2584579 + 426 WP_003905869.1 type II toxin-antitoxin system VapC family toxin Toxin
PAK35_RS11950 (PAK35_11950) 2584602..2585783 - 1182 WP_003905870.1 dihydrolipoamide acetyltransferase family protein -
PAK35_RS11955 (PAK35_11955) 2585780..2586826 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
PAK35_RS11960 (PAK35_11960) 2586837..2587940 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
PAK35_RS11965 (PAK35_11965) 2588199..2589020 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
PAK35_RS11970 (PAK35_11970) 2589017..2589574 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15364.84 Da        Isoelectric Point: 9.2386

>T267118 WP_003905869.1 NZ_CP115447:2584154-2584579 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRASTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT267118 WP_003412749.1 NZ_CP115447:2583927-2584148 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5R1ZCY8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References