Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2141722..2142417 Replicon chromosome
Accession NZ_CP115447
Organism Mycobacterium tuberculosis strain BLR 9248 2019

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PAK35_RS09825 Protein ID WP_003905754.1
Coordinates 2141722..2142156 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag PAK35_RS09830 Protein ID WP_003410814.1
Coordinates 2142163..2142417 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAK35_RS09815 (PAK35_09815) 2137876..2140917 + 3042 WP_003899171.1 DEAD/DEAH box helicase -
PAK35_RS09820 (PAK35_09820) 2140910..2141743 + 834 WP_003899172.1 SWIM zinc finger family protein -
PAK35_RS09825 (PAK35_09825) 2141722..2142156 - 435 WP_003905754.1 type II toxin-antitoxin system VapC family toxin Toxin
PAK35_RS09830 (PAK35_09830) 2142163..2142417 - 255 WP_003410814.1 antitoxin Antitoxin
PAK35_RS09835 (PAK35_09835) 2142433..2142690 - 258 WP_003410816.1 hypothetical protein -
PAK35_RS09840 (PAK35_09840) 2143224..2144485 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
PAK35_RS09850 (PAK35_09850) 2146353..2146649 + 297 WP_003410820.1 PE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15632.05 Da        Isoelectric Point: 7.4681

>T267116 WP_003905754.1 NZ_CP115447:c2142156-2141722 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTASEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT267116 WP_003410814.1 NZ_CP115447:c2142417-2142163 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References