Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK(toxin)
Location 2098388..2099024 Replicon chromosome
Accession NZ_CP115447
Organism Mycobacterium tuberculosis strain BLR 9248 2019

Toxin (Protein)


Gene name mazF Uniprot ID P0CL62
Locus tag PAK35_RS09630 Protein ID WP_003410654.1
Coordinates 2098614..2099024 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P9WJ84
Locus tag PAK35_RS09625 Protein ID WP_003410651.1
Coordinates 2098388..2098621 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAK35_RS09610 (PAK35_09610) 2093836..2094237 + 402 WP_009937711.1 metal ABC transporter permease -
PAK35_RS09615 (PAK35_09615) 2094238..2094642 - 405 WP_003410645.1 PPOX class F420-dependent oxidoreductase -
PAK35_RS09620 (PAK35_09620) 2094726..2098310 - 3585 WP_003910889.1 cobaltochelatase subunit CobN -
PAK35_RS09625 (PAK35_09625) 2098388..2098621 + 234 WP_003410651.1 type II toxin-antitoxin system antitoxin MazE7 Antitoxin
PAK35_RS09630 (PAK35_09630) 2098614..2099024 + 411 WP_003410654.1 type II toxin-antitoxin system toxin endoribonuclease MazF7 Toxin
PAK35_RS09635 (PAK35_09635) 2099008..2100099 + 1092 WP_003900454.1 precorrin-3B synthase -
PAK35_RS09640 (PAK35_09640) 2100109..2100735 + 627 WP_003410658.1 precorrin-8X methylmutase -
PAK35_RS09645 (PAK35_09645) 2100732..2102258 + 1527 WP_003410659.1 precorrin-2 C(20)-methyltransferase -
PAK35_RS09650 (PAK35_09650) 2102204..2103427 - 1224 WP_003901321.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14235.42 Da        Isoelectric Point: 10.6228

>T267115 WP_003410654.1 NZ_CP115447:2098614-2099024 [Mycobacterium tuberculosis]
MAEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTPLRPPVAPSEGVAADSVAVCRGV
RAVARARLVERLGALKPATMRAIENALTLILGLPTGPERGEAATHSPVRWTGGRDP

Download         Length: 411 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8450.25 Da        Isoelectric Point: 4.7954

>AT267115 WP_003410651.1 NZ_CP115447:2098388-2098621 [Mycobacterium tuberculosis]
MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAIFRAEREASHAETTTQAVRDEDREWEGTVGDGLG

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7DU4
PDB 5WYG
PDB 6A6X

Antitoxin

Source ID Structure
PDB 7DU4
PDB 6A6X
AlphaFold DB A0A7U4BV50

References