Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2027887..2028513 Replicon chromosome
Accession NZ_CP115447
Organism Mycobacterium tuberculosis strain BLR 9248 2019

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag PAK35_RS09320 Protein ID WP_003410075.1
Coordinates 2028115..2028513 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JLL8
Locus tag PAK35_RS09315 Protein ID WP_003911750.1
Coordinates 2027887..2028114 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAK35_RS09305 (PAK35_09305) 2025926..2026270 - 345 WP_003410065.1 ferredoxin family protein -
PAK35_RS09310 (PAK35_09310) 2026459..2027628 - 1170 WP_003899126.1 ATP-binding protein -
PAK35_RS09315 (PAK35_09315) 2027887..2028114 + 228 WP_003911750.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PAK35_RS09320 (PAK35_09320) 2028115..2028513 + 399 WP_003410075.1 PIN domain nuclease Toxin
PAK35_RS09325 (PAK35_09325) 2028696..2029127 - 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
PAK35_RS09330 (PAK35_09330) 2029228..2029662 + 435 WP_003914358.1 DUF1398 domain-containing protein -
PAK35_RS09335 (PAK35_09335) 2030099..2030278 - 180 Protein_1851 hypothetical protein -
PAK35_RS09340 (PAK35_09340) 2030366..2030986 + 621 WP_003410086.1 IS110 family transposase -
PAK35_RS09345 (PAK35_09345) 2030940..2031530 + 591 WP_003899131.1 IS110 family transposase -
PAK35_RS09350 (PAK35_09350) 2031658..2032914 - 1257 WP_003902247.1 HNH endonuclease signature motif containing protein -
PAK35_RS09355 (PAK35_09355) 2033268..2033468 + 201 Protein_1855 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T267113 WP_003410075.1 NZ_CP115447:2028115-2028513 [Mycobacterium tuberculosis]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8346.16 Da        Isoelectric Point: 4.1621

>AT267113 WP_003911750.1 NZ_CP115447:2027887-2028114 [Mycobacterium tuberculosis]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure
AlphaFold DB A0A806JLL8

References