Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1995257..1995945 Replicon chromosome
Accession NZ_CP115447
Organism Mycobacterium tuberculosis strain BLR 9248 2019

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag PAK35_RS09150 Protein ID WP_003409958.1
Coordinates 1995257..1995676 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag PAK35_RS09155 Protein ID WP_003409968.1
Coordinates 1995685..1995945 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAK35_RS09125 (PAK35_09125) 1991112..1991324 - 213 Protein_1809 class I SAM-dependent methyltransferase -
PAK35_RS09130 (PAK35_09130) 1991328..1991600 + 273 Protein_1810 SAM-dependent methyltransferase -
PAK35_RS09135 (PAK35_09135) 1991563..1993008 - 1446 WP_003899115.1 APC family permease -
PAK35_RS09140 (PAK35_09140) 1993187..1993873 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
PAK35_RS09145 (PAK35_09145) 1994064..1995032 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
PAK35_RS09150 (PAK35_09150) 1995257..1995676 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
PAK35_RS09155 (PAK35_09155) 1995685..1995945 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PAK35_RS09160 (PAK35_09160) 1996088..1997764 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
PAK35_RS09165 (PAK35_09165) 1997752..1998405 - 654 WP_003409976.1 cutinase Cfp21 -
PAK35_RS09170 (PAK35_09170) 1998520..1998750 + 231 WP_003409980.1 DUF167 domain-containing protein -
PAK35_RS09175 (PAK35_09175) 1998835..1999746 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
PAK35_RS09180 (PAK35_09180) 1999855..2000454 + 600 WP_003910883.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T267110 WP_003409958.1 NZ_CP115447:c1995676-1995257 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT267110 WP_003409968.1 NZ_CP115447:c1995945-1995685 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References