Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1742492..1742952 Replicon chromosome
Accession NZ_CP115447
Organism Mycobacterium tuberculosis strain BLR 9248 2019

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag PAK35_RS07950 Protein ID WP_003898996.1
Coordinates 1742704..1742952 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag PAK35_RS07945 Protein ID WP_003408528.1
Coordinates 1742492..1742704 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAK35_RS07930 (PAK35_07930) 1738970..1740157 - 1188 WP_003898992.1 nitrate transporter NarK -
PAK35_RS07935 (PAK35_07935) 1740444..1740728 + 285 WP_003408522.1 DUF1876 domain-containing protein -
PAK35_RS07940 (PAK35_07940) 1740742..1742424 - 1683 WP_003901239.1 SulP family inorganic anion transporter -
PAK35_RS07945 (PAK35_07945) 1742492..1742704 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PAK35_RS07950 (PAK35_07950) 1742704..1742952 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
PAK35_RS07955 (PAK35_07955) 1742960..1743697 + 738 WP_003898997.1 hypothetical protein -
PAK35_RS07960 (PAK35_07960) 1743791..1745491 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
PAK35_RS07965 (PAK35_07965) 1745776..1746177 - 402 WP_003408538.1 hypothetical protein -
PAK35_RS07970 (PAK35_07970) 1746167..1746778 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T267106 WP_003898996.1 NZ_CP115447:1742704-1742952 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT267106 WP_003408528.1 NZ_CP115447:1742492-1742704 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References