267105

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1721668..1722281 Replicon chromosome
Accession NZ_CP115447
Organism Mycobacterium tuberculosis strain BLR 9248 2019

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PAK35_RS07835 Protein ID WP_003910864.1
Coordinates 1721668..1722057 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag PAK35_RS07840 Protein ID WP_003408469.1
Coordinates 1722054..1722281 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAK35_RS07800 (PAK35_07800) 1717297..1718211 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
PAK35_RS07805 (PAK35_07805) 1718214..1719044 + 831 WP_003408448.1 cyclase family protein -
PAK35_RS07810 (PAK35_07810) 1719044..1719394 + 351 WP_003898986.1 cupin domain-containing protein -
PAK35_RS07815 (PAK35_07815) 1719447..1720265 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
PAK35_RS07820 (PAK35_07820) 1720279..1721058 + 780 WP_003408460.1 IclR family transcriptional regulator -
PAK35_RS07830 (PAK35_07830) 1721489..1721620 + 132 Protein_1550 IS3 family transposase -
PAK35_RS07835 (PAK35_07835) 1721668..1722057 - 390 WP_003910864.1 type II toxin-antitoxin system VapC family toxin Toxin
PAK35_RS07840 (PAK35_07840) 1722054..1722281 - 228 WP_003408469.1 antitoxin Antitoxin
PAK35_RS07845 (PAK35_07845) 1722499..1723983 + 1485 WP_003408473.1 biotin carboxylase -
PAK35_RS07850 (PAK35_07850) 1723980..1725227 + 1248 WP_003408476.1 serine hydrolase -
PAK35_RS07855 (PAK35_07855) 1725270..1725689 - 420 WP_003408483.1 hypothetical protein -
PAK35_RS07860 (PAK35_07860) 1725679..1726389 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(3-117)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13837.02 Da        Isoelectric Point: 7.4232

>T267105 WP_003910864.1 NZ_CP115447:c1722057-1721668 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVRAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT267105 WP_003408469.1 NZ_CP115447:c1722281-1722054 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAN9

References