Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1547266..1547879 Replicon chromosome
Accession NZ_CP115447
Organism Mycobacterium tuberculosis strain BLR 9248 2019

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag PAK35_RS07080 Protein ID WP_003407786.1
Coordinates 1547475..1547879 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8UJ46
Locus tag PAK35_RS07075 Protein ID WP_009935474.1
Coordinates 1547266..1547469 (+) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAK35_RS07045 (PAK35_07045) 1542671..1543051 + 381 WP_003407768.1 fumarate reductase subunit C -
PAK35_RS07050 (PAK35_07050) 1543048..1543425 + 378 WP_003407771.1 fumarate reductase subunit FrdD -
PAK35_RS07055 (PAK35_07055) 1543493..1544101 + 609 WP_003407773.1 TetR/AcrR family transcriptional regulator -
PAK35_RS07060 (PAK35_07060) 1544285..1545433 + 1149 Protein_1398 MMPL family transporter -
PAK35_RS07065 (PAK35_07065) 1545443..1545889 + 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
PAK35_RS07070 (PAK35_07070) 1545924..1547213 + 1290 WP_003407781.1 threonine ammonia-lyase -
PAK35_RS07075 (PAK35_07075) 1547266..1547469 + 204 WP_009935474.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PAK35_RS07080 (PAK35_07080) 1547475..1547879 + 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
PAK35_RS07085 (PAK35_07085) 1547896..1549638 - 1743 WP_003407788.1 malto-oligosyltrehalose trehalohydrolase -
PAK35_RS07090 (PAK35_07090) 1549631..1551928 - 2298 WP_003407790.1 malto-oligosyltrehalose synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T267104 WP_003407786.1 NZ_CP115447:1547475-1547879 [Mycobacterium tuberculosis]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7501.48 Da        Isoelectric Point: 4.3951

>AT267104 WP_009935474.1 NZ_CP115447:1547266-1547469 [Mycobacterium tuberculosis]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 204 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6A7V

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8UJ46

References