Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1354805..1355460 Replicon chromosome
Accession NZ_CP115447
Organism Mycobacterium tuberculosis strain BLR 9248 2019

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA6
Locus tag PAK35_RS06230 Protein ID WP_003898861.1
Coordinates 1354805..1355206 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag PAK35_RS06235 Protein ID WP_003407272.1
Coordinates 1355203..1355460 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAK35_RS06215 (PAK35_06215) 1350277..1351662 - 1386 WP_003407260.1 cytochrome P450 -
PAK35_RS06220 (PAK35_06220) 1351740..1352774 + 1035 WP_003407264.1 AraC family transcriptional regulator -
PAK35_RS06225 (PAK35_06225) 1352820..1354550 - 1731 WP_009940170.1 PE family protein -
PAK35_RS06230 (PAK35_06230) 1354805..1355206 - 402 WP_003898861.1 type II toxin-antitoxin system VapC family toxin Toxin
PAK35_RS06235 (PAK35_06235) 1355203..1355460 - 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
PAK35_RS06240 (PAK35_06240) 1355543..1356502 - 960 WP_003407276.1 alpha/beta hydrolase -
PAK35_RS06245 (PAK35_06245) 1356527..1357489 - 963 WP_003905554.1 alpha/beta hydrolase -
PAK35_RS06250 (PAK35_06250) 1357488..1358225 + 738 WP_031647000.1 lysoplasmalogenase -
PAK35_RS06255 (PAK35_06255) 1358306..1360273 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14952.43 Da        Isoelectric Point: 11.4656

>T267102 WP_003898861.1 NZ_CP115447:c1355206-1354805 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT267102 WP_003407272.1 NZ_CP115447:c1355460-1355203 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045ISB0

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References