Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1167794..1168353 Replicon chromosome
Accession NZ_CP115447
Organism Mycobacterium tuberculosis strain BLR 9248 2019

Toxin (Protein)


Gene name relE Uniprot ID G0THS1
Locus tag PAK35_RS05415 Protein ID WP_003898789.1
Coordinates 1167794..1168087 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0THS2
Locus tag PAK35_RS05420 Protein ID WP_003406322.1
Coordinates 1168084..1168353 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAK35_RS05390 (PAK35_05390) 1163492..1163752 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 -
PAK35_RS05395 (PAK35_05395) 1163749..1164180 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin -
PAK35_RS05400 (PAK35_05400) 1164203..1165786 - 1584 WP_271095676.1 PE family protein -
PAK35_RS05405 (PAK35_05405) 1165966..1166826 + 861 WP_003900301.1 glycine betaine ABC transporter substrate-binding protein -
PAK35_RS05410 (PAK35_05410) 1166907..1167737 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
PAK35_RS05415 (PAK35_05415) 1167794..1168087 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
PAK35_RS05420 (PAK35_05420) 1168084..1168353 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PAK35_RS05425 (PAK35_05425) 1168466..1172161 - 3696 WP_003406323.1 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit -
PAK35_RS05430 (PAK35_05430) 1172303..1173091 - 789 WP_003406325.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11031.57 Da        Isoelectric Point: 9.6275

>T267100 WP_003898789.1 NZ_CP115447:c1168087-1167794 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Download         Length: 294 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9766.97 Da        Isoelectric Point: 4.8615

>AT267100 WP_003406322.1 NZ_CP115447:c1168353-1168084 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THS1

Antitoxin

Source ID Structure
AlphaFold DB G0THS2

References