267099

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1163492..1164180 Replicon chromosome
Accession NZ_CP115447
Organism Mycobacterium tuberculosis strain BLR 9248 2019

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag PAK35_RS05395 Protein ID WP_003406304.1
Coordinates 1163749..1164180 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag PAK35_RS05390 Protein ID WP_003406302.1
Coordinates 1163492..1163752 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAK35_RS05370 (PAK35_05370) 1159069..1159893 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
PAK35_RS05375 (PAK35_05375) 1159898..1161079 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
PAK35_RS05380 (PAK35_05380) 1161156..1162256 - 1101 WP_003406300.1 magnesium/cobalt transporter CorA -
PAK35_RS05385 (PAK35_05385) 1162427..1163416 + 990 WP_003406301.1 malate dehydrogenase -
PAK35_RS05390 (PAK35_05390) 1163492..1163752 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
PAK35_RS05395 (PAK35_05395) 1163749..1164180 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
PAK35_RS05400 (PAK35_05400) 1164203..1165786 - 1584 WP_271095676.1 PE family protein -
PAK35_RS05405 (PAK35_05405) 1165966..1166826 + 861 WP_003900301.1 glycine betaine ABC transporter substrate-binding protein -
PAK35_RS05410 (PAK35_05410) 1166907..1167737 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
PAK35_RS05415 (PAK35_05415) 1167794..1168087 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
PAK35_RS05420 (PAK35_05420) 1168084..1168353 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T267099 WP_003406304.1 NZ_CP115447:1163749-1164180 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT267099 WP_003406302.1 NZ_CP115447:1163492-1163752 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References