Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 638540..639216 Replicon chromosome
Accession NZ_CP115447
Organism Mycobacterium tuberculosis strain BLR 9248 2019

Toxin (Protein)


Gene name vapC Uniprot ID G0TPQ9
Locus tag PAK35_RS02870 Protein ID WP_003898500.1
Coordinates 638540..638953 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TPR0
Locus tag PAK35_RS02875 Protein ID WP_003402915.1
Coordinates 638950..639216 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAK35_RS02840 (PAK35_02840) 633885..634187 - 303 WP_003402896.1 DUF3349 domain-containing protein -
PAK35_RS02845 (PAK35_02845) 634247..634525 - 279 WP_003402901.1 hypothetical protein -
PAK35_RS02850 (PAK35_02850) 634522..635775 - 1254 WP_003402904.1 inorganic phosphate transporter -
PAK35_RS02855 (PAK35_02855) 635895..636281 - 387 WP_003402907.1 VOC family protein -
PAK35_RS02860 (PAK35_02860) 636344..637228 - 885 WP_003402909.1 SDR family oxidoreductase -
PAK35_RS02865 (PAK35_02865) 637324..638226 - 903 WP_003915439.1 1,4-dihydroxy-2-naphthoyl-CoA synthase -
PAK35_RS02870 (PAK35_02870) 638540..638953 - 414 WP_003898500.1 type II toxin-antitoxin system VapC family toxin Toxin
PAK35_RS02875 (PAK35_02875) 638950..639216 - 267 WP_003402915.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
PAK35_RS02880 (PAK35_02880) 639408..641123 - 1716 WP_003402917.1 fatty-acid--CoA ligase FadD8 -
PAK35_RS02885 (PAK35_02885) 641201..642805 + 1605 WP_003402920.1 amidohydrolase -
PAK35_RS02890 (PAK35_02890) 642802..643782 + 981 WP_003402923.1 o-succinylbenzoate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(13-129)

Antitoxin

Post-segregation antitoxin CcdA

(19-61)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14667.78 Da        Isoelectric Point: 7.3603

>T267092 WP_003898500.1 NZ_CP115447:c638953-638540 [Mycobacterium tuberculosis]
VRASPTSPPEQVVVDASAMVDLLARTSDRCSAVRARLARTAMHAPAHFDAEVLSALGRMQRAGALTVAYVDAALEELRQV
PVTRHGLSSLLAGAWSRRDTLRLTDALYVELAETAGLVLLTTDERLARAWPSAHAIG

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9543.79 Da        Isoelectric Point: 4.5994

>AT267092 WP_003402915.1 NZ_CP115447:c639216-638950 [Mycobacterium tuberculosis]
MLSRRTKTIVVCTLVCMARLNVYVPDELAERARARGLNVSALTQAAISAELENSATDAWLEGLEPRSTGARHDDVLGAID
AARDEFEA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPQ9

Antitoxin

Source ID Structure
AlphaFold DB G0TPR0

References