Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-ParD |
| Location | 442465..443476 | Replicon | chromosome |
| Accession | NZ_CP115447 | ||
| Organism | Mycobacterium tuberculosis strain BLR 9248 2019 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | L7N5R2 |
| Locus tag | PAK35_RS01910 | Protein ID | WP_003401859.1 |
| Coordinates | 442465..443058 (-) | Length | 198 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | O53702 |
| Locus tag | PAK35_RS01915 | Protein ID | WP_003401860.1 |
| Coordinates | 443087..443476 (-) | Length | 130 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PAK35_RS01890 (PAK35_01890) | 438114..439496 | + | 1383 | WP_003898415.1 | magnesium transporter | - |
| PAK35_RS01895 (PAK35_01895) | 439508..440542 | - | 1035 | WP_003401856.1 | class II fructose-bisphosphate aldolase | - |
| PAK35_RS01900 (PAK35_01900) | 440638..441321 | + | 684 | WP_003401857.1 | VTT domain-containing protein | - |
| PAK35_RS01905 (PAK35_01905) | 441310..442440 | - | 1131 | WP_003401858.1 | glycoside hydrolase family 76 protein | - |
| PAK35_RS01910 (PAK35_01910) | 442465..443058 | - | 594 | WP_003401859.1 | zeta toxin family protein | Toxin |
| PAK35_RS01915 (PAK35_01915) | 443087..443476 | - | 390 | WP_003401860.1 | hypothetical protein | Antitoxin |
| PAK35_RS01920 (PAK35_01920) | 443557..444768 | - | 1212 | WP_003401861.1 | VWA domain-containing protein | - |
| PAK35_RS01925 (PAK35_01925) | 444774..445376 | - | 603 | WP_003898417.1 | SRPBCC family protein | - |
| PAK35_RS01930 (PAK35_01930) | 445390..446286 | - | 897 | WP_003898418.1 | MoxR family ATPase | - |
| PAK35_RS01935 (PAK35_01935) | 446283..446876 | - | 594 | WP_003401864.1 | NTP transferase domain-containing protein | - |
| PAK35_RS01940 (PAK35_01940) | 446873..447628 | - | 756 | WP_003401865.1 | XdhC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 198 a.a. Molecular weight: 21344.53 Da Isoelectric Point: 10.5018
>T267091 WP_003401859.1 NZ_CP115447:c443058-442465 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA
Download Length: 594 bp
Antitoxin
Download Length: 130 a.a. Molecular weight: 13648.21 Da Isoelectric Point: 6.0829
>AT267091 WP_003401860.1 NZ_CP115447:c443476-443087 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP
Download Length: 390 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BRU8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BRT0 |