Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 362153..362796 Replicon chromosome
Accession NZ_CP115447
Organism Mycobacterium tuberculosis strain BLR 9248 2019

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag PAK35_RS01575 Protein ID WP_003401566.1
Coordinates 362371..362796 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag PAK35_RS01570 Protein ID WP_003401563.1
Coordinates 362153..362374 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAK35_RS01545 (PAK35_01545) 357272..358075 - 804 WP_003401540.1 Stf0 family sulphotransferase -
PAK35_RS01550 (PAK35_01550) 358085..359482 - 1398 WP_003401544.1 sulfatase -
PAK35_RS01555 (PAK35_01555) 359661..361436 + 1776 WP_010886074.1 PE family protein -
PAK35_RS01560 (PAK35_01560) 361579..361806 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
PAK35_RS01565 (PAK35_01565) 361803..362105 + 303 WP_003401560.1 toxin-antitoxin system toxin -
PAK35_RS01570 (PAK35_01570) 362153..362374 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
PAK35_RS01575 (PAK35_01575) 362371..362796 + 426 WP_003401566.1 PIN domain nuclease Toxin
PAK35_RS01580 (PAK35_01580) 362932..363564 + 633 WP_003905275.1 TetR/AcrR family transcriptional regulator -
PAK35_RS01585 (PAK35_01585) 363561..364469 + 909 WP_031714300.1 SDR family NAD(P)-dependent oxidoreductase -
PAK35_RS01590 (PAK35_01590) 364477..365067 - 591 WP_229298012.1 hypothetical protein -
PAK35_RS01595 (PAK35_01595) 365060..365110 - 51 Protein_315 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T267090 WP_003401566.1 NZ_CP115447:362371-362796 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT267090 WP_003401563.1 NZ_CP115447:362153-362374 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References