Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Rv0298-Rv0299/- |
Location | 361579..362105 | Replicon | chromosome |
Accession | NZ_CP115447 | ||
Organism | Mycobacterium tuberculosis strain BLR 9248 2019 |
Toxin (Protein)
Gene name | Rv0299 | Uniprot ID | - |
Locus tag | PAK35_RS01565 | Protein ID | WP_003401560.1 |
Coordinates | 361803..362105 (+) | Length | 101 a.a. |
Antitoxin (Protein)
Gene name | Rv0298 | Uniprot ID | P9WJ08 |
Locus tag | PAK35_RS01560 | Protein ID | WP_003401555.1 |
Coordinates | 361579..361806 (+) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PAK35_RS01545 (PAK35_01545) | 357272..358075 | - | 804 | WP_003401540.1 | Stf0 family sulphotransferase | - |
PAK35_RS01550 (PAK35_01550) | 358085..359482 | - | 1398 | WP_003401544.1 | sulfatase | - |
PAK35_RS01555 (PAK35_01555) | 359661..361436 | + | 1776 | WP_010886074.1 | PE family protein | - |
PAK35_RS01560 (PAK35_01560) | 361579..361806 | + | 228 | WP_003401555.1 | ribbon-helix-helix protein, CopG family | Antitoxin |
PAK35_RS01565 (PAK35_01565) | 361803..362105 | + | 303 | WP_003401560.1 | toxin-antitoxin system toxin | Toxin |
PAK35_RS01570 (PAK35_01570) | 362153..362374 | + | 222 | WP_003401563.1 | type II toxin-antitoxin system antitoxin VapB2 | - |
PAK35_RS01575 (PAK35_01575) | 362371..362796 | + | 426 | WP_003401566.1 | PIN domain nuclease | - |
PAK35_RS01580 (PAK35_01580) | 362932..363564 | + | 633 | WP_003905275.1 | TetR/AcrR family transcriptional regulator | - |
PAK35_RS01585 (PAK35_01585) | 363561..364469 | + | 909 | WP_031714300.1 | SDR family NAD(P)-dependent oxidoreductase | - |
PAK35_RS01590 (PAK35_01590) | 364477..365067 | - | 591 | WP_229298012.1 | hypothetical protein | - |
PAK35_RS01595 (PAK35_01595) | 365060..365110 | - | 51 | Protein_315 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 10442.16 Da Isoelectric Point: 4.9609
>T267088 WP_003401560.1 NZ_CP115447:361803-362105 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC
Download Length: 303 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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