267083

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 239592..240234 Replicon chromosome
Accession NZ_CP115307
Organism Bacillus cereus strain BC-01

Toxin (Protein)


Gene name pemK Uniprot ID R8I8B8
Locus tag GVV68_RS05395 Protein ID WP_000635965.1
Coordinates 239884..240234 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag GVV68_RS05390 Protein ID WP_000004570.1
Coordinates 239592..239879 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVV68_RS05365 (GVV68_05365) 234909..235871 + 963 WP_000961161.1 UV DNA damage repair endonuclease UvsE -
GVV68_RS05370 (GVV68_05370) 235864..236436 - 573 WP_000908523.1 rhomboid family intramembrane serine protease -
GVV68_RS05375 (GVV68_05375) 236530..236889 + 360 WP_087948187.1 holo-ACP synthase -
GVV68_RS05380 (GVV68_05380) 237046..237996 + 951 WP_002060618.1 outer membrane lipoprotein carrier protein LolA -
GVV68_RS05385 (GVV68_05385) 238114..239283 + 1170 WP_000390617.1 alanine racemase -
GVV68_RS05390 (GVV68_05390) 239592..239879 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
GVV68_RS05395 (GVV68_05395) 239884..240234 + 351 WP_000635965.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
GVV68_RS05400 (GVV68_05400) 240302..242470 + 2169 WP_000426236.1 Tex family protein -
GVV68_RS05405 (GVV68_05405) 242528..242644 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
GVV68_RS05410 (GVV68_05410) 242840..243298 + 459 WP_000344240.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12948.04 Da        Isoelectric Point: 5.7168

>T267083 WP_000635965.1 NZ_CP115307:239884-240234 [Bacillus cereus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMSRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT267083 WP_000004570.1 NZ_CP115307:239592-239879 [Bacillus cereus]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A366G118

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References