Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 2722374..2723016 Replicon chromosome
Accession NZ_CP115303
Organism Bacillus tropicus strain JMT105-2

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag AVT_RS13900 Protein ID WP_000635963.1
Coordinates 2722374..2722724 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag AVT_RS13905 Protein ID WP_000004570.1
Coordinates 2722729..2723016 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVT_RS13885 (AVT_13885) 2719310..2719768 - 459 WP_087967857.1 SprT family protein -
AVT_RS13890 (AVT_13890) 2719964..2720080 + 117 WP_001143642.1 cortex morphogenetic protein CmpA -
AVT_RS13895 (AVT_13895) 2720138..2722306 - 2169 WP_270184594.1 Tex family protein -
AVT_RS13900 (AVT_13900) 2722374..2722724 - 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
AVT_RS13905 (AVT_13905) 2722729..2723016 - 288 WP_000004570.1 antitoxin EndoAI Antitoxin
AVT_RS13910 (AVT_13910) 2723325..2724494 - 1170 WP_048553601.1 alanine racemase -
AVT_RS13915 (AVT_13915) 2724614..2725564 - 951 WP_131102695.1 outer membrane lipoprotein carrier protein LolA -
AVT_RS13920 (AVT_13920) 2725721..2726080 - 360 WP_000635047.1 holo-ACP synthase -
AVT_RS13925 (AVT_13925) 2726173..2726721 + 549 WP_087967862.1 rhomboid family intramembrane serine protease -
AVT_RS13930 (AVT_13930) 2726889..2727851 - 963 WP_087967864.1 UV DNA damage repair endonuclease UvsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T267082 WP_000635963.1 NZ_CP115303:c2722724-2722374 [Bacillus tropicus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT267082 WP_000004570.1 NZ_CP115303:c2723016-2722729 [Bacillus tropicus]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References