26708

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2203459..2203973 Replicon chromosome
Accession NC_017347
Organism Staphylococcus aureus subsp. aureus T0131

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag SAT0131_RS11170 Protein ID WP_000581792.1
Coordinates 2203459..2203668 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag SAT0131_RS11175 Protein ID WP_000138932.1
Coordinates 2203680..2203973 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAT0131_RS11150 2198967..2200325 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
SAT0131_RS11155 2200340..2201410 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
SAT0131_RS11160 2201728..2202930 + 1203 WP_001109939.1 rod shape-determining protein RodA -
SAT0131_RS11165 2203194..2203331 - 138 WP_000828354.1 hypothetical protein -
SAT0131_RS11170 2203459..2203668 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
SAT0131_RS11175 2203680..2203973 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
SAT0131_RS11180 2204139..2205623 + 1485 WP_000571549.1 cardiolipin synthase -
SAT0131_RS11185 2205651..2206298 + 648 WP_001187629.1 HD domain-containing protein -
SAT0131_RS11200 2207127..2207981 - 855 WP_000725804.1 membrane protein insertase YidC -
SAT0131_RS11205 2208067..2208708 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T26708 WP_000581792.1 NC_017347:c2203668-2203459 [Staphylococcus aureus subsp. aureus T0131]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T26708 NC_017347:c2203668-2203459 [Staphylococcus aureus subsp. aureus T0131]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT26708 WP_000138932.1 NC_017347:c2203973-2203680 [Staphylococcus aureus subsp. aureus T0131]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT26708 NC_017347:c2203973-2203680 [Staphylococcus aureus subsp. aureus T0131]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References