Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 712297..712961 Replicon chromosome
Accession NZ_CP115184
Organism Janibacter cremeus strain SCSIO 52865

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag O9K63_RS03225 Protein ID WP_277240486.1
Coordinates 712566..712961 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag O9K63_RS03220 Protein ID WP_277240484.1
Coordinates 712297..712569 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O9K63_RS03205 (O9K63_03205) 709721..710344 + 624 WP_277240478.1 LON peptidase substrate-binding domain-containing protein -
O9K63_RS03210 (O9K63_03210) 710412..711638 - 1227 WP_277240480.1 MFS transporter -
O9K63_RS03215 (O9K63_03215) 711770..712078 + 309 WP_277240482.1 putative quinol monooxygenase -
O9K63_RS03220 (O9K63_03220) 712297..712569 + 273 WP_277240484.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
O9K63_RS03225 (O9K63_03225) 712566..712961 + 396 WP_277240486.1 type II toxin-antitoxin system VapC family toxin Toxin
O9K63_RS03230 (O9K63_03230) 712969..713784 - 816 WP_277240488.1 class I SAM-dependent methyltransferase -
O9K63_RS03235 (O9K63_03235) 713928..715421 + 1494 WP_277240489.1 methyltransferase domain-containing protein -
O9K63_RS03240 (O9K63_03240) 715388..716074 - 687 WP_277240490.1 dihydrofolate reductase family protein -
O9K63_RS03245 (O9K63_03245) 716071..716958 - 888 WP_277240492.1 lysylphosphatidylglycerol synthase transmembrane domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 691654..713784 22130


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(1-89)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14200.87 Da        Isoelectric Point: 4.2433

>T267076 WP_277240486.1 NZ_CP115184:712566-712961 [Janibacter cremeus]
MIIDTSALVAIITGEPEADRLLTAIAEAESARMSAATYVECAIVIDRRSSPATRRRFDQLLTTLEIGIADLTADQAQIAR
EAHRDFGRGSEGRARLNLGDCYSYALAVASDDELLFQGDDFSATDIVAARY

Download         Length: 396 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10079.27 Da        Isoelectric Point: 5.1802

>AT267076 WP_277240484.1 NZ_CP115184:712297-712569 [Janibacter cremeus]
MAMNIKNERVHELAREAARRAGTTQTSVLEAALEQYLEVLRAEDGTSGTAAKLVRARDIVHRMRSDMTDEQRSGIRHDLE
ALYDEDGLPA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References