Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | rlegTA/AbiEii-AbiEi |
| Location | 721046..722181 | Replicon | chromosome |
| Accession | NZ_CP115174 | ||
| Organism | Sphingomonas sp. PAMB00755 | ||
Toxin (Protein)
| Gene name | rlegT | Uniprot ID | - |
| Locus tag | PBT88_RS03475 | Protein ID | WP_270077845.1 |
| Coordinates | 721651..722181 (+) | Length | 177 a.a. |
Antitoxin (Protein)
| Gene name | rlegA | Uniprot ID | - |
| Locus tag | PBT88_RS03470 | Protein ID | WP_270077844.1 |
| Coordinates | 721046..721654 (+) | Length | 203 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PBT88_RS03445 (PBT88_03445) | 716285..716431 | + | 147 | Protein_676 | IS256 family transposase | - |
| PBT88_RS03450 (PBT88_03450) | 716623..717690 | - | 1068 | WP_270077841.1 | AraC family transcriptional regulator | - |
| PBT88_RS03455 (PBT88_03455) | 718045..718617 | + | 573 | Protein_678 | alpha/beta fold hydrolase | - |
| PBT88_RS03460 (PBT88_03460) | 718935..719516 | + | 582 | WP_270077842.1 | MFS transporter | - |
| PBT88_RS03465 (PBT88_03465) | 719630..720673 | + | 1044 | WP_270077843.1 | DUF1176 domain-containing protein | - |
| PBT88_RS03470 (PBT88_03470) | 721046..721654 | + | 609 | WP_270077844.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
| PBT88_RS03475 (PBT88_03475) | 721651..722181 | + | 531 | WP_270077845.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| PBT88_RS03480 (PBT88_03480) | 722667..723953 | + | 1287 | WP_270077846.1 | hypothetical protein | - |
| PBT88_RS03485 (PBT88_03485) | 724149..725210 | + | 1062 | WP_270077847.1 | hypothetical protein | - |
| PBT88_RS03490 (PBT88_03490) | 725309..726004 | + | 696 | WP_270077848.1 | DNA adenine methylase | - |
| PBT88_RS03495 (PBT88_03495) | 726001..727128 | + | 1128 | WP_270077849.1 | cysteine desulfurase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 699392..728059 | 28667 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 177 a.a. Molecular weight: 19390.27 Da Isoelectric Point: 6.4897
>T267064 WP_270077845.1 NZ_CP115174:721651-722181 [Sphingomonas sp. PAMB00755]
MSRPPKNMAMSVRDRLTARARERRENAQLLMTRYVIERLLFRLSLSPHRERFVLKGAMLFSLWTAAPYRATGDLDLLGMG
ENAPEQLAAIFQEILAVTVDDDGIVFRPETLRAAAARAEDEYSGVRIDFVAELAGARLPMHVDIGFGDAITPGAMALGQG
GSFDGEWPSGGPWKAK
MSRPPKNMAMSVRDRLTARARERRENAQLLMTRYVIERLLFRLSLSPHRERFVLKGAMLFSLWTAAPYRATGDLDLLGMG
ENAPEQLAAIFQEILAVTVDDDGIVFRPETLRAAAARAEDEYSGVRIDFVAELAGARLPMHVDIGFGDAITPGAMALGQG
GSFDGEWPSGGPWKAK
Download Length: 531 bp
Antitoxin
Download Length: 203 a.a. Molecular weight: 22218.65 Da Isoelectric Point: 9.1571
>AT267064 WP_270077844.1 NZ_CP115174:721046-721654 [Sphingomonas sp. PAMB00755]
VETTTHRERALAVVRHCGIARGRDFDAAGVTRATLQRLRDEGVLQQVGRGLYKLADADVDSATSLAEAVRIQPRGIICLL
SALQFHELTTQTPHAVWMMLGQKDWAPVNPSVALKIVRASGEALTAGVETQVIDGVPVPITVPAKTVADCFKHRNKIGID
VAVEALRDFMKSRPRPDLNAIYRYAQLDRVQSVIRPYLEAMT
VETTTHRERALAVVRHCGIARGRDFDAAGVTRATLQRLRDEGVLQQVGRGLYKLADADVDSATSLAEAVRIQPRGIICLL
SALQFHELTTQTPHAVWMMLGQKDWAPVNPSVALKIVRASGEALTAGVETQVIDGVPVPITVPAKTVADCFKHRNKIGID
VAVEALRDFMKSRPRPDLNAIYRYAQLDRVQSVIRPYLEAMT
Download Length: 609 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|