Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3219908..3220544 Replicon chromosome
Accession NZ_CP115172
Organism Bacillus safensis strain BS-10L

Toxin (Protein)


Gene name mazF Uniprot ID A0A0P7G713
Locus tag ORQ91_RS16445 Protein ID WP_024425388.1
Coordinates 3219908..3220258 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag ORQ91_RS16450 Protein ID WP_003214273.1
Coordinates 3220263..3220544 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORQ91_RS16405 (ORQ91_03283) 3214939..3215538 - 600 WP_024425395.1 PP2C family serine/threonine-protein phosphatase -
ORQ91_RS16410 (ORQ91_03284) 3215538..3216326 - 789 WP_024425394.1 RNA polymerase sigma factor SigB -
ORQ91_RS16415 (ORQ91_03285) 3216292..3216780 - 489 WP_024425393.1 anti-sigma B factor RsbW -
ORQ91_RS16420 (ORQ91_03286) 3216777..3217106 - 330 WP_024425392.1 anti-sigma factor antagonist -
ORQ91_RS16425 (ORQ91_03287) 3217166..3218173 - 1008 WP_024425391.1 PP2C family protein-serine/threonine phosphatase -
ORQ91_RS16430 (ORQ91_03288) 3218184..3218585 - 402 WP_073203956.1 anti-sigma regulatory factor -
ORQ91_RS16435 (ORQ91_03289) 3218588..3218956 - 369 WP_003214235.1 RsbT antagonist protein RsbS -
ORQ91_RS16440 (ORQ91_03290) 3218961..3219791 - 831 WP_044334717.1 RsbT co-antagonist protein RsbRA -
ORQ91_RS16445 (ORQ91_03291) 3219908..3220258 - 351 WP_024425388.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
ORQ91_RS16450 (ORQ91_03292) 3220263..3220544 - 282 WP_003214273.1 hypothetical protein Antitoxin
ORQ91_RS16455 (ORQ91_03293) 3220839..3222014 - 1176 WP_103132680.1 alanine racemase -
ORQ91_RS16460 (ORQ91_03294) 3222156..3223172 - 1017 WP_087975235.1 outer membrane lipoprotein-sorting protein -
ORQ91_RS16465 (ORQ91_03295) 3223333..3223698 - 366 WP_047202005.1 holo-ACP synthase -
ORQ91_RS16470 (ORQ91_03296) 3223793..3224398 + 606 WP_024425384.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8891

>T267062 WP_024425388.1 NZ_CP115172:c3220258-3219908 [Bacillus safensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT267062 WP_003214273.1 NZ_CP115172:c3220544-3220263 [Bacillus safensis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P7G713

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References