Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1197654..1198571 Replicon chromosome
Accession NZ_CP115158
Organism Bacillus amyloliquefaciens strain MBLB 0692

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag O7R04_RS06280 Protein ID WP_025851786.1
Coordinates 1197825..1198571 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag O7R04_RS06275 Protein ID WP_003154807.1
Coordinates 1197654..1197824 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O7R04_RS06235 (O7R04_06235) 1192885..1194507 + 1623 WP_058905960.1 pyocin knob domain-containing protein -
O7R04_RS06240 (O7R04_06240) 1194520..1194891 + 372 WP_014304856.1 XkdW family protein -
O7R04_RS06245 (O7R04_06245) 1194897..1195094 + 198 WP_003154819.1 XkdX family protein -
O7R04_RS06250 (O7R04_06250) 1195151..1195912 + 762 WP_058905961.1 hypothetical protein -
O7R04_RS06255 (O7R04_06255) 1195964..1196227 + 264 WP_003154815.1 hemolysin XhlA family protein -
O7R04_RS06260 (O7R04_06260) 1196241..1196504 + 264 WP_003154813.1 phage holin -
O7R04_RS06265 (O7R04_06265) 1196518..1197396 + 879 WP_014304858.1 N-acetylmuramoyl-L-alanine amidase -
O7R04_RS06270 (O7R04_06270) 1197432..1197557 - 126 WP_003154809.1 hypothetical protein -
O7R04_RS06275 (O7R04_06275) 1197654..1197824 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
O7R04_RS06280 (O7R04_06280) 1197825..1198571 - 747 WP_025851786.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
O7R04_RS06285 (O7R04_06285) 1198675..1199673 - 999 WP_003154805.1 inorganic phosphate transporter -
O7R04_RS06290 (O7R04_06290) 1199686..1200303 - 618 WP_003154804.1 DUF47 domain-containing protein -
O7R04_RS06295 (O7R04_06295) 1200589..1201905 - 1317 WP_003154801.1 amino acid permease -
O7R04_RS06300 (O7R04_06300) 1202229..1203179 + 951 WP_015388352.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29048.53 Da        Isoelectric Point: 4.7003

>T267060 WP_025851786.1 NZ_CP115158:c1198571-1197825 [Bacillus amyloliquefaciens]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVVGAMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYGEKMNVTASL
CEYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQDRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT267060 WP_003154807.1 NZ_CP115158:c1197824-1197654 [Bacillus amyloliquefaciens]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References