Detailed information of TA system TA026706

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2130900..2131405
• Replicon: chromosome
• Accession: NC_017347
• Organism: Staphylococcus aureus subsp. aureus T0131

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: SAT0131_RS10795
• Protein ID: WP_001103948.1
• Coordinates: 2130900..2131193 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IY59
• Locus tag: SAT0131_RS10800
• Protein ID: WP_001058494.1
• Coordinates: 2131196..2131405 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAT0131_RS10765	2126003..2126344	-	342	WP_001190605.1	hypothetical protein	-
SAT0131_RS10770	2126881..2127522	-	642	WP_001019785.1	hypothetical protein	-
SAT0131_RS10775	2127519..2127803	-	285	WP_000998180.1	hypothetical protein	-
SAT0131_RS10780	2127805..2128167	-	363	WP_001039167.1	hypothetical protein	-
SAT0131_RS10785	2128469..2129926	-	1458	WP_000432707.1	virulence-associated E family protein	-
SAT0131_RS10790	2129943..2130812	-	870	WP_001002692.1	primase alpha helix C-terminal domain-containing protein	-
SAT0131_RS10795	2130900..2131193	-	294	WP_001103948.1	DUF1474 family protein	Toxin
SAT0131_RS10800	2131196..2131405	-	210	WP_001058494.1	hypothetical protein	Antitoxin
SAT0131_RS10805	2131398..2131544	-	147	WP_000784885.1	hypothetical protein	-
SAT0131_RS10810	2131541..2131858	-	318	WP_000481967.1	helix-turn-helix domain-containing protein	-
SAT0131_RS10815	2131863..2132081	-	219	WP_000153640.1	helix-turn-helix transcriptional regulator	-
SAT0131_RS10820	2132254..2132928	+	675	WP_000620857.1	helix-turn-helix transcriptional regulator	-
SAT0131_RS10825	2132942..2134114	+	1173	WP_000179344.1	site-specific integrase	-
SAT0131_RS10830	2134183..2135799	-	1617	WP_000240653.1	chaperonin GroEL	-
SAT0131_RS10835	2135875..2136159	-	285	WP_000917289.1	co-chaperone GroES	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / groEL	2064958..2136159	71201

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-97)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11576.05 Da
• Isoelectric Point: 4.9594

>T26706 WP_001103948.1 NC_017347:c2131193-2130900 [Staphylococcus aureus subsp. aureus T0131]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSGSYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASLQADQSESNA

Nucleotide

• Length: 294 bp

>T26706 NC_017347:c2131193-2130900 [Staphylococcus aureus subsp. aureus T0131]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGGTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAAGTGTACTTAAAAGAGTTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCGTCACTTCAAGCCGACCAAAGCGAAAGTAACGCATAG

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8268.31 Da
• Isoelectric Point: 4.3718

>AT26706 WP_001058494.1 NC_017347:c2131405-2131196 [Staphylococcus aureus subsp. aureus T0131]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNSIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT26706 NC_017347:c2131405-2131196 [Staphylococcus aureus subsp. aureus T0131]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATAGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Antitoxin

• AlphaFold DB: X5IY59